Hipófisis Flashcards

1
Q

Diagnóstico de deficiencia de GH

A

Evalúo IGF-1

Hipoglucemia inducida por insulina/prueba de tolerancia a insulina

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2
Q

Tx de deficiencia GH

A

0.025mg/kg/día de GH recombinante

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3
Q

% de las mutaciones activadores de Gsa que están sin identificarse

A

60-65%

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4
Q

5 signos/síntomas de acromegalia

A
Prognatismo
Galactorrea en mujeres y disfunción reproductiva en ambos
Túnel del carpo
Voz apagada y resonante
Apnea del sueno
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5
Q

Principal causa de mortalidad en px con acromegalia

A

Enfermedades CV y EVC

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6
Q

Dx de acromegalia

A

Niveles de IGF-1

Prueba de supresión con glucosa, GH 6>ng/dl es diagnóstica

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7
Q

Tx. de acromegalia por tumor

A

Cirugía transesfenoidal

Farmacológico:

Análogos de somatostatina: octreótido y pasireótido 40-60mg/día cada 38 días por 24 semanas

Antagonista del receptor de GH: pegvisomant

Agonistas de dopamina

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8
Q

Tx prolactinoma

A

Agonistas dopaminérgicos: bromocriptina, carbegolina

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9
Q

Tx enf de Cushing

A

Ketoconazol
Metirapona
Etomidato
Mitotano

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