Female reproductive physiology

Question 1

oestrogen, LH, FSH

Pragnancy hormonal screening features

Answer 1

• High oestrogen
• Low LH/FSH

-ve feedback from oestrogen

Question 2

Primary ovarian failure hormonal screening features

Answer 2

• Low AMH
• Low oestrogen
• High LH/FSH

Low AMH = reduced ovarian func.

Question 3

Hypothalamic hypogonadism hormonal screening features

Answer 3

• Low LH/FSH/oestrogen

due to lack of GnRH

Question 4

Define Adrenarche

Answer 4

The maturation of adrenal glands, leading to increased production of androgens (e.g., DHEA-S)

Question 5

At what age do Adrenarche occur

Answer 5

6-8 years

Question 6

Adrenarche hallmarks

Answer 6

Pubic/axillary hair
body odor
mild acne

Question 7

Define Gonadarche

Answer 7

HPG axis activation → ovarian/testicular maturation

Question 8

At what age in female does Gonadarche occur

Answer 8

8-13 years

Question 9

Gonadarche hallmarks in girls

Answer 9

Breast budding - Initiates secondary sexual characteristics

Question 10

Define Pubarche

Answer 10

First pubic hair

Question 11

Define Thelarche

Answer 11

Onset of breast development - Breast budding (Tanner B2)

Question 12

Define Menarche

Answer 12

The first menstrual period

Question 13

Puberty order for girls

Answer 13

• Adrenarche
• Gonadarche
• Thelarche
• Pubarche
• Menarche