Pre-eclampsia & Eclampsia Flashcards
(17 cards)
Define Pre-eclampsia
new-onset hypertension (≥140/90 mmHg) after 20 weeks of pregnancy, with one or more of the following:
- Proteinuria (urine protein:creatinine ratio ≥30 mg/mmol or dipstick ≥2+).
- Maternal organ dysfunction:
- Renal: Serum creatinine ≥90 µmol/L.
- Hepatic: Alanine transaminase (ALT) ≥70 IU/L or right upper quadrant pain.
- Hematological: Platelets < 150,000/µL or hemolysis.
- Neurological: Severe headache, visual disturbances, or eclampsia (seizures).
Pre-eclampsia diagnostic criteria
- Mild: 140/90–159/109 mmHg.
- Severe: ≥160/110 mmHg.
what anti-hypertensive should be avoided in pre-eclampsia and why
ACE-i / ARBs - teratogenic
Pre-eclampsia prophylaxis medication
Aspirin 75-150mg
when should Aspirin prophylaxis Tx start
from 12 wks until birth
who should receive aspirin prophylaxis
- existing HTN
- DM
- autoimmune
- Hx of pre-eclampsia
- Multifetal
- BMI >35
Pre-eclampsia 1st line Tx
- Labetalol oral / IV
- Nifidipine m/r
- Methyldopa
what is used for seizure (eclampsia) prophylaxis in pre-eclampsia
Mg sulphate IV
Pre-eclampsia Sx
- Severe headache
- Swelling
- Vision problem
- Vomiting
Pre-eclampsia Risk factors
- Hx of HTN during preg
- Existing renal insuff
- Autoimm disease
Pre-eclampsia Dx Ix
- Urinalysis
- Urine ACR
- BP
Definitive solution for pre-eclampsia
Delivering the baby
Pre-eclampsia complications
- HELLP syndrome
- Eclampsia
Define Eclampsia
the occurrence of one or more seizures (fits) in a woman with pre-eclampsia that cannot be attributed to other causes.
Eclampsia Sx
- Prodrome: severe headache, visual disturbances, epigastric pain, and altered mental status
- generalised tonic-clonic
At what BP should women with Pre-eclampsia be admitted
> 160/110
Pre eclampsia Urine PCR criteria
≥30 mg/mmol
