Final - Adverse Effects Flashcards
(101 cards)
1
Q
- jaundice
- photosensitivity
- overdose: ventricular arrhythmias
A
imipramine
2
Q
SSRIs
A
ped. pt’s: personality disorder
3
Q
Which antineoplastic causes radiation recall phenomenon = sore skin
A
doxorubicin
4
Q
which opioid:
- confusion, dizziness, drowsiness, sedation
A
fentanyl
5
Q
cephalosporins
A
C. Diff
6
Q
uterine rupture
A
carbaprost
7
Q
Potassium Channel Blockers
A
prolonged QT interval = torsades = lead to v. fib
8
Q
which biological response modifier causes:
- HA
- arthralgia
- dizziness
- abdominal pain
- 7% bone pain & rebound thrombocytopenia
A
romiplostim
9
Q
- resp. depression
- CNS depression
- high doses: hallucinations & seizures
- cerebral vasodilation: increase CSF pressure
- N, V, C (it affects the medulla in the brain = N/V) (opioids slow down the GI tract) = watch for bowel habits & treat bowel blockages
- peripheral vasodilation = orthostatic hypotension
- spasm of sphincter oddi
- urinary retention (due to increasing bladder sphincter tone)
- pruritus (itching)
A
opioids
10
Q
which biological response modifier causes neutropenic fever
A
filgrastin
11
Q
Which anti-thyroid:
- hepatotoxicity
- leukopenia, thrombocytopenia = monitor CBC
- decrease bone marrow reserve with lactation & pregnancy
A
mathimazole
12
Q
oligohydraminos (too little amniotic fluid)
A
indomethacin
13
Q
Which tocolytic causes flushing (usually in cheeks, but can in legs too)
A
nifedipine
14
Q
- ventricular dysrhythmias
- hypotension
- Class IV HF at high risk for life-threatening cardiovascular reactions
A
milrinone
15
Q
- nephrotoxicity
- anaphylaxis when given IV
- increase risk of secondary cancer
A
cyclosporine
16
Q
thrombolytics
A
extreme risk of bleeding
17
Q
most common side effect for mehtylergonovine
A
uterine cramping
18
Q
- rash
- diarrhea
- superinfections
A
cefazolin
19
Q
which antidiabetic meds causes hypokalemia
A
regular
20
Q
flumazenil
A
high risk for seizures
21
Q
which biological response modifier causes HTN, seizures, & neutralizing antibodies = rapid cell aplasia
A
epoetin alfa
22
Q
which opioid:
- accumulation of metabolite = toxicity = tremors, seizures, irreversible with antagonist
A
meperdine
23
Q
- CNS stimulation: nervousness, insomnia, but it can have a sedative effect on some
- ped pt’s: decreased overall ht & wt.
- increase BP 10-15 mmHg
- sexual dysfunction
A
venlaxafine
24
Q
- little or not wt. gain, hypotension, dysrhythmias, anticholinergic effects, or prolactin release
- drowsiness
- seizures
A
aripiprazole
25
- cardiovascular collapse
- CNS effects
- urinary retention, menstrual irregularities
- laryngeal spasm & cough
diazepam
26
constriction of ducuts arteriosis
indomethacine
27
- excessive sweating, somnolence, anxiety, male function disorders
- decreased appetite
- HTN
desvenlaxafine
28
- parenteral: CNS stimulation
- reflex bradycardia
- reduced blood flow to tissues
phenylephrine
29
Propranolol
- bronchospaspa
| - SJS = report s/s hives
30
initial adverse effect of lithium carbonate
muscle weakness, n/v, lethargy, polyuria, nocturia, HA, dizziness, drowsiness, tremors, confusion
31
which thrombolytic can cause fever
streptokinase
32
Which vasodilator:
- flushing
- HA
- blurred vision
- syncope
nitroglycerine
33
- dizziness
| - gynecomastia, menstrual abnormalities, impotence (has effect on reproductive hormone levels)
spironalactone
34
metronidazole
peripheral neuropathy
35
- anticholinergic
- wt. gain
- anemia = check CBCs
- blurred vision, glaucoma
- increase QT interval causing possible dysrhythmias = don't administer tricyclics
haloperidol
36
Which anti-thyroid:
- N,V
- rash
- stomach pain
potassium iodide
37
Rapid IV aminocaproic acid =
hypotension or bradycardia
38
fluconazole
Stevens-Johnson syndrome in immunosuppressed
39
Vancomycin
1. Red man Syndrome = run slowly over 60 minutes, flushing, rash
2. Nephrotoxicity (hard on kidneys)
3. Confusion, seizures, hallucinations, anaphylactic reaction (from running it too fast or too high dose)
40
Which Calcium Channel Blocker:
- HA
- dizziness
- edema
Diltiazem
41
long-term adverse effects of lithium carbonate
- can produce toxicity including kidney impairment, dysrhythmias, circulatory collapse, and leukocytosis
- can cause hypothyroidism & goiter
42
Calcium Channel Blockers
DON'T LET PT'S TAKE BETA-BLCOKERS & CALCIUM CHANNEL BLOCKERS TOGETHER!!!
43
Antipsychotics
1. EPS
- acute dystonia: sever muscle spams
- akasthasia: inability to rest or relax
- parkinsonism: tremors, loss of fine motor skills, muscle rigidity, shuffling gait
- tardive dyskinesia: involuntary unusual tongue & face movements
NMS: high fever, diaphoresis, muscle rigidity, tachycardia, BP fluctuations. Potenitally fatal if medication not discontinued
44
which biological response modifier causes ANC above 100,000 cell/mm = resp. failure, intracranial hemorrhage, or MI
filgrastin
45
- anxiety, confusion
- peptic ulcer disease
- increased BS
- impaired wound healing
hydrocortisone
46
cyclophosphamide
- sterility in M & F
| - myelosuppression = dose limiting factor
47
Adenosime
self-limiting due to 10-second half-life
48
- low incidence of EPS
| - possible lens changes
quetiapine
49
Which antineoplastic causes GI toxicity
vincristine
50
which biological response modifier causes bone pain (in long bones, sternum, ribs, pelvis, etc)
filgrastin
51
Tricyclics have _____ effects
anticholinergic
52
benzos
may increase of decreased effectiveness of birth control
53
Heparin
heparin-induced thrombocytopenia (increases platelet aggregation & thrombolytic events = scary & dangerous)
54
- orthostatic hypotension
- life-threatening dysrhythmias (prolongs QT interval = torsades) = don't give K+ channel blockers
- sedation, confusion, dizziness
tricyclic antidepressants
55
rare adverse effect of venlaxafine
rectal, vaginal, uterin hemorrhage
56
- insomnia, loss of concentration
- confusion = notify physician
- previous psychiatric disorder = can worsen mental problems
- renal impaired = hallucinations, seizures
amantadine
57
hydrocortisone
- prolonged use/high dosage = Cushing's
| - osteoporosis
58
desmopressin
- water intoxication: edema, crackles, JVD = HTN = monitor daily wt
59
- hypovolemia = orthostatic hypotention & syncope
- increase BG
- hyperuricemia = can exacerbate gout
* *- ototoxicity (when pushed quickly can cause damage to cochlear ner)
furosemide
60
- dizziness
- paradoxical CNS stimulation can occur in psychiatric pt's, the eldery, & hyperactive children (nightmares, talkativeness, mania, sleep disorders, etc.)
lorazepam
61
Which antineoplastic causes jaundice (because its metabolized through liver) = may have hepatotoxicity
cyclophosphamide
62
Which antineoplastic causes alopecia
cyclophosphamide
63
will terbutaline increase of decrease mom & baby HR
increase
64
- long-term use = increase ALT, AST
- nephrotoxicity
- neurotoxicity
acyclovir
65
rare adverse effect of alteplase
angioedema & incracranial bleeding
66
- abnormal bleeding (epistaxis)
| - possible lethargy to animal products (bc it's taken from beef & pig)
heparin
67
Which oxytocics causes explosive diarrhea
carbaprost
68
do you have an increase or decreased in urine output with mannitol
increase
69
Which antineoplastic causes neurotoxicity = check reflexes & parasthesias
vincristine
70
Lidocaine
lidocaine toxicity: confusion, anxiety, tremors, seizures, comatose, resp. arrest
71
nitroprusside sodium
thiocyanate poisoning
72
- photosensitivity
- bruising, thrombophlebitis
- insomnia, anorexia, anxiety
duloxetine
73
- change urine pink or red-brown
- CNS
- CV
- GI
- Hem: anema = watch CBC
- Derm: rashes = report to MD
phenytoin
74
lopinavir with ritonavir
long-term = lipodystropy pancreatitis (life-threatening)
75
efarirenz
- nightmares
| - dizziness
76
most common adverse effect of duloxetine
abnormal vision
77
Which oxytocic causes fever
carbaprost = order acetominophen
78
Which antineoplastic causes red urine/tears
doxorubicin
79
- nasal congestion
- hypotension
- induce mydriases
phenylephrine
80
Which antineoplastic causes hemorrhagic cystitis
cyclophosphamide
81
epinephrine
extravasation can lead to necrosis = stop infusion & aspirate med out
82
Which Sodium Channel Blocker:
- fever
- anorexia
- psychosis
procainamide
83
does bupropion cause wt gain or sexual dysfunction
NO!!!
84
- CNS stimulation
- wt. loss
- anticholinergic effects
- infants receiving breastmilk from mothers on this med: seizures
bupropion
85
- tachycardia, arrhythmias, & hypotension = increase myocardial workload & O2 consumption
- cardiac arrest
- HF
- shock
dobutamine
86
propofol
propofol infusion syndrome: usually associated with prolonged high-dose infusion = metabolic acidosis, hyperkalemia, lipemia, rhabdomyolysis, hepatomegaly, cardiac & renal failure
87
Which vasodilator:
- HA
- orthostatic hypotension
- fluid retention (because of increase in aldosterone = retains Na+ & H2O = administer with diuretic and/ore beta-blocker)
- peripheral edema
- blood dyscrasia
- lupus-like syndrome up to 9 yrs
hydralazine
88
- bleeding @ puncture site or internally
| - transient dysrhythmias
alteplase
89
- flu-like symptoms
- blood dyscrasias
- orange discoloration of urine, sweat, & tears
rifampin
90
- v. tach c high doses
- extravasation = lead to necrosis
- snake, heart, & lungs
dopamine
91
- HTN
- dysrhythmias
- pulmonary edema
- cardiac arrest
- serious CNS stimulation
- snake, heart, & lungs
epinephrine
92
Which antineoplastic causes increase risk of secondary malignancies
cyclophosphamide
93
Which Calcium Channel Blocker:
- bradycardia
- HF
- SJS
verapamil
94
- anticholinergics
- elevated prolactin levels resulting in galactorrhea, impotence, gynecomastia (check prolactin levels), & menstrual irregularities
- hyperglycemia
- orthostatic hypotenstion
risperidone
95
rare adverse effect of aminocaproic acid
myopathy which can lead to rhabdomyolysis = monitor CPK
96
water intoxication
oxytocin
97
- reflex bradycardia
- dysrhythmias
- s/s overdose = blurred vision & photophobia
- snake, heart
norepinephrine
98
phosphodiesterase III Inhibitor
serious toxicity that limit use to clients with resistant HF
99
- ototoxicity
- nephrotoxicity (805) = BUN & creatinine
- hopokalemia
- hepatotoxic = AST & ALT
amphotericin B
100
- dizziness
- optic nerve inflammation
- psychosis
isoniazide
101
abciximab
- hypotension
- back & chest pain
- thrombocytopenia
