FINAL EXAM CHAPTER 19 Harvesting Electrons from the Cycle Flashcards
What is the starting and end material of the citric acid cycle?
It starts with Acetyl CoA and releases CO2, 8 electrons from NADH and FADH2, and also releases ATP
How many stages does a Citric acid cycle have?
2 stages
What is the key role of the citric acid cycle?
it is the production of high energy electrons on FAD and NAD and captured in the form of NADH and FADH2
What are the intermediates in this cycle used for?
Biosynthetic pathways
Why is the first step so exergonic?
(cleavage of high energy thioester)
Because you are releasing a very high energy bond
Where does the energy come from for the formation of ATP from ADP?
(Thioester bond of succinyl CoA)
This comes from the high energy released by the cleavage of the thioester of Succinyl CoA
What is the role of Histidine in the mechanism of Succinyl CoA synthetase?
It moves the phosphate to ADP
What does Aconitase catalyze ?
Citrate conversion to Isocitrate
What does Isocitrate dehydrogenase catalyze and what does is use up and release?
Isocitrate conversion to α-ketoglutarate
uses NAD+ and release NADH+CO2
What does α-Ketoglutarate dehydrogenase complex catalyze and what does it use up and release?
α-ketoglutarate conversion to Succinyl CoA
Uses NAD+ +CoA and release NADH+CO2
What does Succinyl CoA catalyze and what does it use up and release?
Succinyl CoA conversion into Succinate
uses up ADP+Pi and releases ATP and CO2
What does Succinate dehydrogenase catalyze and what does it use up and release?
Succinate conversion into Fumarate
Uses up FAD and releases FADH2
What does Fumarase catalyze and what does it use up and release?
Fumarate conversion into Malate
uses up H2O
What does Malate dehydrogenase catalyze and what does it use up and release?
Malate conversion into Oxaloacetate
uses up NAD+ and releases NADH+H
What does Citric synthase catalyze and what does it use up and release?
Oxaloacetate conversion into Citrate
uses up H2O and succinyl CoA and releases CoA
