final lecture 1

Question 1

factor 2a

Answer 1

thrombin

Question 2

factor 2

Answer 2

prothrombin

Question 3

factor 1a

Answer 3

fibrin

Question 4

what factors need Ca to be activated?

Answer 4

9->9a, 10->10a, 2->2a, 7->9a

Question 5

neutropenia

Answer 5

abnormally low number of neutrophils

Question 6

mild neutropenia

Answer 6

1000<1500- minimal risk of infection

Question 7

moderate neutropenia

Answer 7

500<1000- moderate risk of infection

Question 8

severe neutropenia

Answer 8

ANC<500- severe risk of infection

Question 9

thrombocytopenia

Answer 9

decrease in plts <100,000

Question 10

causes of decreased plts

Answer 10

decreased production
increased destruction
medication induced-myelosuppression

Question 11

hematopoietic growth factors are active at ____

Answer 11

low concentrations

Question 12

networking

Answer 12

hematopoietic growth factors interacting synergistically with other factors

Question 13

proteins produced in prokaryotes(bacteria)

Answer 13

show no glycosylation (Carb moiety)

Question 14

proteins produced in eukaryotes(yeast, mammals)

Answer 14

are glycosylated

Question 15

stem cell factor (SCF) is a

Answer 15

cytokein/hematopoietic growth factor involved in regulation of early stages of hematopoeisis

Question 16

SCF exerts its effects by binding to the

Answer 16

c-Kit receptor (CD117)

Question 17

soluble c-kit receptor

Answer 17

is a naturally occurring molecule that counteracts effects of SCF

Question 18

ancestim

Answer 18

soluble SCF made from e.coli; SQ; kidneys

Question 19

G-CSF actions

Answer 19

protects neutrophils from apoptosis & enhances their function & controls migration of mature neutrophils from the marrow->blood

Question 20

most abundant G-CSF

Answer 20

174

Question 21

filgrastim

Answer 21

recombinant G-CSF; e.coli; treat severe neutropenia; kidneys; may damage spleen

Question 22

pegfilgrastin

Answer 22

pegylated recombinant G-CSF through conjugation w/ polyethylene glycol moiety; minimizes glomerular filtration; >T1/2

Question 23

GM-CSF stimulates production of

Answer 23

all granulocytes & monocytes

Question 24

GM-CSF receptor

Answer 24

CD116

Question 25

sargramostim

Answer 25

recombinant GM-CSF; yeast

Question 26

sargramostim uses

Answer 26

myeloid recostitiution after bone marrow transplant; treatment of neutropenia induced chemo

Question 27

____ stimulates hematopoiesis

Answer 27

IL-11

Question 28

oprelvekin

Answer 28

non-glycosylated IL-11; prevention of thrombocytopenia & reduction of platelet transfusions; fluid retention & cardiac symptoms

Question 29

thrombopoietin (TPO) is produced by

Answer 29

liver & kidney

Question 30

TPO blood levels are ____ related to blood platelet count

Answer 30

inversely

Question 31

rHuMGDF

Answer 31

truncated version of TPO; bacteria

Question 32

rHuTPO

Answer 32

full length TPO; human

Question 33

romiplostim

Answer 33

fusion protein analog of TPO; indicated for long-term treatment for chronic idiopathic thrombocytopenic purpura (ITP)- antibodies against platelets

Question 34

elfrombopag

Answer 34

agonist of c-mpl receptor CD110; ORAL; ITP treatment & thrombocytopeinia in pts w/ chronic Hep C; hepatotoxicity

Question 35

EPO is produced in

Answer 35

the kidney in response to anemia & hypoxia; can cause iron deficiency

Question 36

epoietin alpha

Answer 36

human EPO nearly identical to endogenous form

Question 37

dabepoietin alpha

Answer 37

modified form of epoietin alpha in which 4 amino acids have been mutated to increase Carb side chains-> longer T1/2