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Flashcards in final lecture 1 Deck (37):
1

factor 2a

thrombin

2

factor 2

prothrombin

3

factor 1a

fibrin

4

what factors need Ca to be activated?

9->9a, 10->10a, 2->2a, 7->9a

5

neutropenia

abnormally low number of neutrophils

6

mild neutropenia

1000<1500- minimal risk of infection

7

moderate neutropenia

500<1000- moderate risk of infection

8

severe neutropenia

ANC<500- severe risk of infection

9

thrombocytopenia

decrease in plts <100,000

10

causes of decreased plts

decreased production
increased destruction
medication induced-myelosuppression

11

hematopoietic growth factors are active at ____

low concentrations

12

networking

hematopoietic growth factors interacting synergistically with other factors

13

proteins produced in prokaryotes(bacteria)

show no glycosylation (Carb moiety)

14

proteins produced in eukaryotes(yeast, mammals)

are glycosylated

15

stem cell factor (SCF) is a

cytokein/hematopoietic growth factor involved in regulation of early stages of hematopoeisis

16

SCF exerts its effects by binding to the

c-Kit receptor (CD117)

17

soluble c-kit receptor

is a naturally occurring molecule that counteracts effects of SCF

18

ancestim

soluble SCF made from e.coli; SQ; kidneys

19

G-CSF actions

protects neutrophils from apoptosis & enhances their function & controls migration of mature neutrophils from the marrow->blood

20

most abundant G-CSF

174

21

filgrastim

recombinant G-CSF; e.coli; treat severe neutropenia; kidneys; may damage spleen

22

pegfilgrastin

pegylated recombinant G-CSF through conjugation w/ polyethylene glycol moiety; minimizes glomerular filtration; >T1/2

23

GM-CSF stimulates production of

all granulocytes & monocytes

24

GM-CSF receptor

CD116

25

sargramostim

recombinant GM-CSF; yeast

26

sargramostim uses

myeloid recostitiution after bone marrow transplant; treatment of neutropenia induced chemo

27

____ stimulates hematopoiesis

IL-11

28

oprelvekin

non-glycosylated IL-11; prevention of thrombocytopenia & reduction of platelet transfusions; fluid retention & cardiac symptoms

29

thrombopoietin (TPO) is produced by

liver & kidney

30

TPO blood levels are ____ related to blood platelet count

inversely

31

rHuMGDF

truncated version of TPO; bacteria

32

rHuTPO

full length TPO; human

33

romiplostim

fusion protein analog of TPO; indicated for long-term treatment for chronic idiopathic thrombocytopenic purpura (ITP)- antibodies against platelets

34

elfrombopag

agonist of c-mpl receptor CD110; ORAL; ITP treatment & thrombocytopeinia in pts w/ chronic Hep C; hepatotoxicity

35

EPO is produced in

the kidney in response to anemia & hypoxia; can cause iron deficiency

36

epoietin alpha

human EPO nearly identical to endogenous form

37

dabepoietin alpha

modified form of epoietin alpha in which 4 amino acids have been mutated to increase Carb side chains-> longer T1/2