final lecture 7

Question 1

hepatic enzyme that requires vitamin K

Answer 1

gamma-glutamyl carboxylae

Question 2

____ reduces vitamin K to its active form

Answer 2

VKOR

Question 3

chief clinical manifestation of vitamin K deficiency

Answer 3

increased bleeding

Question 4

warfarin is a synthetic derivative of

Answer 4

dicoumarol

Question 5

warfarin is a

Answer 5

racemic mixture

Question 6

which enatiomer is the most potent in warfarin

Answer 6

S!

Question 7

warfarin & protein binding

Answer 7

almost completely bound to proteins

Question 8

warfarin CYP pathways

Answer 8

3A4 & 2C9

Question 9

polymorphisms in ___ account for most of the variability of warfarin

Answer 9

2C9

Question 10

INR is a

Answer 10

mathematical correction of PT

allows for comparison of results between lab and standardized reports

Question 11

large loading dose of warfarin causes

Answer 11

abrupt fall in factor VII and protien C but do not speed up IX, X or II

Question 12

warfarin antidote

Answer 12

vitamin k

Question 13

reduce warfarin effects

Answer 13

cholestyramine, nephrotic syndrom, chronic alcohol, rifampin, vitamin K, prego

Question 14

increase warfarin effects

Answer 14

ABX, vit K deficiency, impaired hepatic function, apsirin, age

Question 15

warfarin is not suitable for

Answer 15

acute intervention