First 25 Flashcards
(7 cards)
What is Insulin Aspart’s brand name? Detemir? Glargine? Lispro? Regular?
What insulin comes in a cartridge?
What is the main dose of all the insulin?
What are the insulins MOA?
Novolog, Levemir, Lantus or Toujeo, Humalog, Humulin R and Novolin R.
Aspart(Novolog)
100 units/mL, 300 units/mL for Glargine(Lantus and Toujeo), 500 units/mL(Humulin R and Novolin R).
Facilitates the uptake of glucose into the cells.
What is exenatide’s brand name? Liraglutide’s? MOA?
When are the GLP-1’s CI’d? What is Bydureon and Liraglutide’s blackbox warning? What are the GLP-1’s dosage forms?
What is the dosing of Exenatide(byetta or bydrueon)? Liraglutide?
Byetta or Bydureon, Saxenda or Victoza Glucagon like GLP-1 analog which increases insulin secretion and decreases glucagon secretion and increases B-cell growth/replication and slows gastric emptying.
History of medullary thyroid carcinoma, patients with multiple endocrine neoplasia syndrome, Pregnancy. Risk of thyroid C-cell tumors. Subcutaneous pens, reconstitution(exenatide).
IR: 5mcg-10mcg BID within 60 minutes prior to meals, XR: 2 mg Subq qweekly. Victoza(DM): 0.6 mg once SQ once daily x 1week then 1.2 mg SQ once daily(max 1.8 mg). Saxenda(weight loss): 0.6-3 mg once daily.
What are Metformin’s brand name? MOA? Dosing?
When is Metformin(Fortamet, Glucophage, Glumetza) CI’d? BBW? What special things to know about Metformin?
What is pioglitazone’s brand name? MOA? Dosing? CI and BBW? Side effects or special things to know?
Fortamet, Glucophage, Glumetza. Decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity. IR: 500mg BID or 850 mg once daily, ER: 500 mg-1000 mg once daily. Solution, tablet, ER.
Severe renal dysfunction, Acute or chronic metabolic acidosis. Lactic Acidosis. N&V, take with food, Titrate dose/XR formula may reduce GI side effects, GI effects go away eventually, ensure hydration and renal dysfunction guidelines
Actos, Selective PPARgamma agonist which improves target cell response to insulin. 15-45 mg once daily. BBW is Congestive Heart Failure, CI’d in NYHA Class 3/4 Heart Failure. Peirpheral edema, worsening HF, weight gains, takes weeks to work.
What is Saxagliptin’s brand name? Sitagliptin? What are Sitagliptin and Metofrmin’s MOA? What is their MOA? When are they CI’d? What are the side effects/special things to know about the DPP-4 inhibitors?
What is Saxagliptin(Onglyza)’s dosing? What is Sitagliptin(Januvia)’s dosing?
What is Sildenafil’s brand name? What is Tadalafil’s brand name? What is their MOA?
What is Sildenafil’s(Viagara) dosing/dosage forms? What is Tadalafil’s(Cialis) dosing/dosage forms? When are they CI’d?
Onglyza , Januvia. Janumet. Inhibits dipeptidyl peptidase IV (DPP-IV) enzyme resulting in prolonged active incretin levels. Hypersensitivity. Congestion, sore throat unlikely, symptoms of pancreatitis, Severe stomach/upper GI pain, persistent N/V.
2.5-5 mg once daily. 100 mg once daily.
Revatio, Viagara. Cialis, Adcirca. Inhibits PDE-5 causing increased levels of cGMP.
ED: 25-100 mg prn 1 hour prior. Pulmonary HTN: 5mg-20mg once daily. Tablet, Suspension reconstituted and IV. ED: 2.5-5 mg once daily or 10-20 mg once daily prn 30 minutes prior. BPH: 5 mg once daily. Headache, flushing, dizziness, priapism.
What is Acyclovir’s brand name? Oseltamivir? Valacyclovir? What is their MOA? What is Acyclovir’s dosing/dosage forms?
What is tamiflu’s dosing/dosage form? What is Valacyclovir’s dosing/dosage form?
When are the antivirals CI’d? What are key points for them?
Zovirax, Tamiflu, Valtrix. Inhibits DNA synthesis and viral replication by competing with deoxyguanosine triphosphate for viral DNA polymerase and being incorporated into viral DNA. Oseltamivir inhibits flu virus Neuraminidase. 200-800 mg 3-5 times daily, capsule, tablet, solution(IV), suspension, Cream, Ointment.
Flu prophylaxis: 75 mg once daily, Flu treatment: 75 mg BID, comes as capsule and suspension. 1000-2000 mg q8-24 hours.
Hypersensitivity. N/V, Headache, Give Oseltamivir within 48 hrs of flu symptoms. Can crystalize in kidney and cause AKI, Malaise.
What is Albuterol’s brand name? Budesonide and Formoterol? Fluticasone and Salmeterol? Ipratropium bromide and albuterol? Budesonide? Fluticasone?What is their MOA?
What is Albuterol’s dosage?
What is Symbicort(Budesonide and Formoterol)’s dosage? Advair’s dosage? Combivents doage?
What is Budesonide’s dosage? Fluticasone’s?
ProAir, Proventil, Ventolin, Vospire. Symbicort. Advair, AirDuo. Combivent. Entocort, Uceris, Rhinocort, Pulmicort. Flonase. Relaxes bronchial smooth muscle by acting on beta 2 receptors. Budesonide suppresses leukocytes.
1-2 inhalations q4-6h prn(comes in 90 mcg, .63, 1.25,.5%) and oral syrup(2mg/5mL) and tablet.
2 inhalations BID 80 or 160 mcg/actuation. 1 inhalation BID for diskus, 2 inhalations BID for HFA. 2 inhalations QID max 12 per day. Ipratropium 20 mcg and albuterol 100 mcg.
9 mg qam for 8 weeks, 1-2 intranasal sprays, inhaled 360 mcg BID up to 720 mcg BID. Suspension, inhalation, cream, lotion, ointment 2 sprays in each nostril daily, 88 mcg BID inhaled.
What special things to know about budesonide? Albuterol?
What special things about symbicort? Advair?
What is Dutasteride’s brand name? Finasteride? What is their MOA? What special things to know about them?
What is Dutasteride’s dosing? Finasteride?
CI’d in primary asthma treatment or hypersensitivity to milk proteins, watch for oral thrush, cough, URTI, diarrhea, decrease GI with food. Use as rescue inhaler, same side effects and watch for milk proteins.
BBW of asthma related death, never use as primary asthma treatment, similar side effects to budesonide. Same BBW, milk proteins, same side effects.
Avodart. Propecia, Proscar. Selectively inhibits 5α-reductase, resulting in inhibition of the conversion of testosterone to dihydrotestosterone and markedly suppressed serum dihydrotestosterone levels. CI’d in pregnant or women of child bearing age. Decreased libido and pregnancy category X. Gynecomastia and impotence in Dutasteride, also CI’d in children and hypersensitive patients.
Capsule- 0.5 mg once daily. Tablet 1,5 mg- 5 mg once daily.
