First Trimester Complications - King Flashcards Preview

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Flashcards in First Trimester Complications - King Deck (19):

The alpha subunit of hCG resembles that of which 3 other hormones?



What is the function of hCG in pregnancy?

In a normal pregnancy, how long should it take observed hCG values to double?

What is the expected hCG level around the time of the first missed menses?

What hCG level should be achieved by 10 weeks gestation?

hCG promotes the maintenence of the progesterone-secreting corpus luteum during the beginning of pregnancy

48 hours

100 mIU/mL

100,000 mIU/mL


What pharmacological usage of hCG is a consequence of the structural similarity between hCG and LH?

Thinking along the same lines, what other pharmacological use might hCG have?

Induce ovulation

Stimulate testosterone production in the male testes


What level of hCG is considered a negative finding on a quantitative serum hCG test?

What is the discriminatory zone of hCG?

<3-5 mIU/mL

The discriminatory zone: 1500-2000 mIU/mL. A transvaginal ultrasound should be able to detect pregnancy at this point.


What is a spontaneous abortion/miscarraige/loss?

What is the proper terminology to use when discussing with a patient?

Fetal loss before 20 weeks and/or delivery of a fetus <500 grams

"pregnancy loss" -> other terminology like 'miscarraige' or 'abortion' carry heavy emotional connotations


Name the mode of abortion/miscarraige

  1. Bleeding with open os without passage of the products of conception. Nonviable pregnancy.
  2. Partial passage of products of conception, open os, variable bleeding. Nonviable pregnancy.
  3. Bleeding or cramping with no passage of tissue and closed os. Fetal heart tones are present (if age appropriate).

  1. Inevitable
  2. Incomplete
  3. Threatened


What is a missed abortion?

Compare embryonic demise to anembryonic demise

Missed abortion: intrauterine demise at <20 weeks without passage of any fetal or placental tissue.

Embryonic demise: embryonic pole is visible, no cardiac activity

Anembryonic demise: gestational sac is present without identifiable embryo


What is a complete abortion?

  • Products of conception completely passed
  • Closed os
  • minimal bleeding
  • uterus well-contracted


Define recurrent pregnancy loss

What is the most common etiology?

What is the chance of a woman with this diagnosis experiencing a live pregnancy in the future?

History of 3 or more spontaneous abortions before 20 weeks

50% are idiopathic



Though most recurrent pregnancy losses are idiopathic, name some other potential causes

  • Anatomic (uterine anomalies, fibroids, adhesions)
  • Endocrine (diabetes, thyroid dysfunction, PCOS)
  • Genetic (translocations, aneupoidy)
  • Immunologic (antiphospholipid syndrome, infection)
  • Environmental (smoking, toxins, medications)


Where are most ectopic pregnancies located?

What is a heterotopic pregnancy?

98% are located in the fallopian tube. Most of these occur in the ampulla.

Co-existing intrauterine and extrauterine pregnancies


Name several risk factors for ectopic pregnancy

  • PID
  • Gonorrhea, chlamydia
  • Previous tubal ligation or previous tubal pregnancy
  • assisted reproductive technologies
  • smoking
  • IUD in situ


What is the key intervention for treatment of ectopic pregnancy?

What is the key medical management strategy for ectopic pregnancy?

Surgical removal



Your patient has an absurdly high hCG level (e.g. 900,000)

Is the fetus actually a Super Saiyan? No really, what's going on here?

Gestational trophoblastic disease (GTD)

A group of rare diagnoses that all arise from abnormal proliferation of trophoblastic tissue


What is the genetic difference(s) between complete and partial molar pregnancies?

Which has a higher incidence of persistent GTD and/or malignancy?

Complete: 46XX or 46XY

Partial: 69XXX, 69XYY, 69XXY

Complete (15-20%) > Partial (1-2%)


Describe the classic ultrasound findings in a complete molar pregnancy


US: "Snowstorm appearance"

Grossly: "grape-like" chorionic villi


Does a complete molar pregnancy contain fetal tissue? 

Does a partial molar pregnancy contain fetal tissue?

No - 2 sets of paternal genes

Yes - 1 maternal and 2 paternal sets of genes


What is the key drug used in the treatment of hydatiform molar pregnancy?



hCG that fails to rise by a minimum of 53% over 48 hours is concerning for what?

Failing intrauterine pregnancy or ectopic pregnancy

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