Fitz- Drug properties you need to know II Flashcards Preview

IHO Week 4 > Fitz- Drug properties you need to know II > Flashcards

Flashcards in Fitz- Drug properties you need to know II Deck (37):
1

What are the three types of immunosuppressives?

Glucocorticoids
Antibiotics
Antibodies

2

What are immune system stimulants?

cytokines

3

Dexamethasone and prednisone are?

Glucocorticoids

4

Cyclosporine and tacrolimus are?

Antibiotics

5

Alentuzumab
Denileukin
Gemtuzumab
Ibritumomab
Rituximab
Tositumomab

are?

Antibodies

6

What are the three cytokines that are immune system stimulants?

IL-2
IFN-alpha
TNF- alpha

7

Drugs that block bcr-abl and block HER2 are drugs that target.....

mutated or over expressed proteins

8

What drugs block bcr-abl?

Dasatinib
imatinib
nilotinib

9

What drugs block Her2?

Lapatanib
Trastuzumab

10

Drugs that block EGFR block....

GFs or GF receptors

11

What are drugs that block EGFR?

Cetuximab
Panitumumab
Erlotinib
Gefitinib
Lapatanib

12

What drug decreases FGF production?

IFN alpha

13

What drug depletes asparagine?

L-asparaginase

14

What drug inhibits proteasome 26?

Bortezomib

15

What drug inhibits HDAC?

Vorinostat

16

What are the three things you can do to block angiogenesis?

Block VEGF
Block mTOR
misc.....

17

What drugs block VEGF?

Bevacizumab

18

What drug blocks mTOR

Everolimus/Temsirolimus
Pazopanib
sorafenib
sunitinib

19

What are the misc drugs taht prevent angiogenesis?

IL-12
IFN-alpha
Thalidomide

20

What are the three drugs that induce differentiation?

Tretinoin (retinoid)
Bearotene (rexionind)
Arsenic trioxide (MISC)

21

What are the EGF drugs that stimulate RBC production?

Darbepoitin
Erythropoietin
Pegepoietin

22

What are the MGFs that stimulate neutrophils and stuff?

Filgastrim
Pegfilgrastim
Sagramostim

23

What does L-asparaginase do?

Turns asparagine to aspartic acid and ammonia. Treating w/ L-asparaginase keeps the cancer cell from getting enough asparagine.

24

What drugs inhibit bcl-abl?

Dasatinib
imatinib
nilotinib

Blocks the activation of TFs via the cascade pathway

25

What drugs target CD20?

Ibritumomab
Rituximab
Tositumab

B lymphocytes

26

What drug targets CD 33?

Gemtuzumab

27

What drug targets CD52?

Alemtuzumab

28

Cylophilin is a protein that allows for calcineurin activation--> decreased secretion of IL-2.

What drug blocks clyclophilin?

Cyclosporine

29

What drugs block EGFR?

CEtuximab, panitumumab
erlotinib
gefitinib
lapatanib

30

What drug decreases production of FGF?

IFN alpha

31

Tacrolimus blocks what protein?

FK binding protein

Allows for calcineurin activation--> decreased secretion of IL-2

32

What drug blocks HER2 hte transmembrane protein overexpressed in breast cancers?

Lapatinib
Trastuzumab

33

What drug inhibits HDAC?

Vorinostat

Keeps chroatin from being trxn silenced

34

What drug prevents a cytokine from inducing and expanding a T cell response?

IL-2

35

What drugs inhibit mTOR?

Everolimus, Terisirolimus
Paopanib
sorafenib
sunitinib

36

What drug inhibits the 26 S proteasome?

Bortezomib

37

What drug inhibits VEGF?

Bevaciximab