Flashcards in Fitz- Drug properties you need to know II Deck (37):
1
What are the three types of immunosuppressives?
Glucocorticoids
Antibiotics
Antibodies
2
What are immune system stimulants?
cytokines
3
Dexamethasone and prednisone are?
Glucocorticoids
4
Cyclosporine and tacrolimus are?
Antibiotics
5
Alentuzumab
Denileukin
Gemtuzumab
Ibritumomab
Rituximab
Tositumomab
are?
Antibodies
6
What are the three cytokines that are immune system stimulants?
IL-2
IFN-alpha
TNF- alpha
7
Drugs that block bcr-abl and block HER2 are drugs that target.....
mutated or over expressed proteins
8
What drugs block bcr-abl?
Dasatinib
imatinib
nilotinib
9
What drugs block Her2?
Lapatanib
Trastuzumab
10
Drugs that block EGFR block....
GFs or GF receptors
11
What are drugs that block EGFR?
Cetuximab
Panitumumab
Erlotinib
Gefitinib
Lapatanib
12
What drug decreases FGF production?
IFN alpha
13
What drug depletes asparagine?
L-asparaginase
14
What drug inhibits proteasome 26?
Bortezomib
15
What drug inhibits HDAC?
Vorinostat
16
What are the three things you can do to block angiogenesis?
Block VEGF
Block mTOR
misc.....
17
What drugs block VEGF?
Bevacizumab
18
What drug blocks mTOR
Everolimus/Temsirolimus
Pazopanib
sorafenib
sunitinib
19
What are the misc drugs taht prevent angiogenesis?
IL-12
IFN-alpha
Thalidomide
20
What are the three drugs that induce differentiation?
Tretinoin (retinoid)
Bearotene (rexionind)
Arsenic trioxide (MISC)
21
What are the EGF drugs that stimulate RBC production?
Darbepoitin
Erythropoietin
Pegepoietin
22
What are the MGFs that stimulate neutrophils and stuff?
Filgastrim
Pegfilgrastim
Sagramostim
23
What does L-asparaginase do?
Turns asparagine to aspartic acid and ammonia. Treating w/ L-asparaginase keeps the cancer cell from getting enough asparagine.
24
What drugs inhibit bcl-abl?
Dasatinib
imatinib
nilotinib
Blocks the activation of TFs via the cascade pathway
25
What drugs target CD20?
Ibritumomab
Rituximab
Tositumab
B lymphocytes
26
What drug targets CD 33?
Gemtuzumab
27
What drug targets CD52?
Alemtuzumab
28
Cylophilin is a protein that allows for calcineurin activation--> decreased secretion of IL-2.
What drug blocks clyclophilin?
Cyclosporine
29
What drugs block EGFR?
CEtuximab, panitumumab
erlotinib
gefitinib
lapatanib
30
What drug decreases production of FGF?
IFN alpha
31
Tacrolimus blocks what protein?
FK binding protein
Allows for calcineurin activation--> decreased secretion of IL-2
32
What drug blocks HER2 hte transmembrane protein overexpressed in breast cancers?
Lapatinib
Trastuzumab
33
What drug inhibits HDAC?
Vorinostat
Keeps chroatin from being trxn silenced
34
What drug prevents a cytokine from inducing and expanding a T cell response?
IL-2
35
What drugs inhibit mTOR?
Everolimus, Terisirolimus
Paopanib
sorafenib
sunitinib
36
What drug inhibits the 26 S proteasome?
Bortezomib
37