Krafts- CLL Flashcards Preview

IHO Week 4 > Krafts- CLL > Flashcards

Flashcards in Krafts- CLL Deck (15):
1

Chronic lymphoproliferative disease is the malignant proliferation of ____________. In the blood and bone marrow. It occurs ONLY in _______ and has a ___________course that is __________.

Lymphocytes
adults
LONG
incurable

2

What is seen in the blood of someone w/ CLL?

Small mature lymphocytes that are boring and all look the same.

3

What are the common characteristics of CLL?

small mature lymphocytes increase in the bone marrow (pt > 40)>
Asymptomatic>
organ infilatration>
hypogammaglobulinemia>
Infection (fatal)

4

What are the immunophenotypic characteristics of CLL?

Positive for : CD20, CD5
Neg: TdT

5

What is the mean survival for CLL?

9 yrs

6

What does hairy cell leukemia look like in the blood and bone marrow?

Blood- hairy cells
Bone marrow- chicken mesh

7

What is an side effect of fibrotic marrow in HCL?

Makes it difficult for RBC to migrate thorugh--> pancytopenia

8

HCL usually presents in/as.....

>40
M
splenomegaly w/ out lymphadenopathy

9

Hairy cells can be selectively stained w/...

TRAP

10

The immunophenytype of hairy cell is....

Pos: B cell ag (CD25, CD11c)
Neg: CD5

11

What is the prognosis for HCL?

10 yrs

12

What are the charcteristics of prolymphocytic leukemia?

Increased prolymphocytes>
splenogmegaly w/ NO lymphadenopathy>
Increased WBC, decreased Hb and platelets

13

Prolymphocytic leukemia is....

aggressive and rare

14

Blood of people w/ prolymphocytic leukemia has....

ceels w/ dark chromatin and nucleoli

15

What are the characteristics of large granulated lylmphocytic leukemia?

T cells w/ granules
Neutropenia--> freq infections
Long survival