Flashcards in Krafts- CLL Deck (15):
Chronic lymphoproliferative disease is the malignant proliferation of ____________. In the blood and bone marrow. It occurs ONLY in _______ and has a ___________course that is __________.
What is seen in the blood of someone w/ CLL?
Small mature lymphocytes that are boring and all look the same.
What are the common characteristics of CLL?
small mature lymphocytes increase in the bone marrow (pt > 40)>
What are the immunophenotypic characteristics of CLL?
Positive for : CD20, CD5
What is the mean survival for CLL?
What does hairy cell leukemia look like in the blood and bone marrow?
Blood- hairy cells
Bone marrow- chicken mesh
What is an side effect of fibrotic marrow in HCL?
Makes it difficult for RBC to migrate thorugh--> pancytopenia
HCL usually presents in/as.....
splenomegaly w/ out lymphadenopathy
Hairy cells can be selectively stained w/...
The immunophenytype of hairy cell is....
Pos: B cell ag (CD25, CD11c)
What is the prognosis for HCL?
What are the charcteristics of prolymphocytic leukemia?
splenogmegaly w/ NO lymphadenopathy>
Increased WBC, decreased Hb and platelets
Prolymphocytic leukemia is....
aggressive and rare
Blood of people w/ prolymphocytic leukemia has....
ceels w/ dark chromatin and nucleoli