Fluoroquinolones, Metronidazole Flashcards
(6 cards)
1
Q
Fluoroquinolones
- Resistance Mechanisms
A
- Change in porin structure decreasing permeability to quinolones
- Decrease affinity for DNA gyrase
- Efflux pumps
2
Q
Fluoroquinolones
- Adverse Effects
A
- Skin Rashes
- GI
- CNS (Hallucinations, Seizures)
- Tendonitis
- Cartilage damage
- Cardiovascular
- Myasthenia Gravis
- Renal
3
Q
Fluoroquinolones
- Counseling
A
- Are only used when no other alternatives
- Ruptures are preceded 2 weeks in advance with pain and inflammation
4
Q
Metronidazole
- Resistance Mechanisms
A
- Decrease uptake into cell
- Decrease nitroreductase activity
5
Q
Metronidazole
- Adverse Effects
A
- Peripheral Neuropathy (Reversible)
- CNS Toxicity (Seizures)
- Neutropenia (Reversible)
6
Q
Metronidazole
- Counseling
A
- Do not drink alcohol (Disulfiram effect of confusion and psychosis)
- Darkents urine to red-brown
- Inhibits CYP 2C9 (Warfarin)
- Increases lithium levels
- Increases Busulfan levels
