Polymyxins, Bacitracin, Fusidic Acid, Mupirocin

Question 1

Bacitracin
- Counseling

Answer 1

Tolerated well topically
- Minor skin irritation (rare contact dermatitis)
- Rare anaphylaxis with open lesions

Crosses with Polymyxin B

Question 2

Polymyxin B
- Counseling

Answer 2

Binds with high affinity to cell membrane
- Little Systemic Absorption

Used to prevent and treat minor skin infections
- Combined with bacitracin and neomycin

Question 3

Colistin
- Counseling

Answer 3

Used IV as a drug of last resort
- Should be used synergistically with other drugs to avoid long interval between doses

• Reversible Nephrotoxicity
• Neurotoxicity

Question 4

Mupirocin
- Counseling

Answer 4

Long term use can lead to resistance against Staph

Prolonged use can lead to fungi growth

Well tolerated

Question 5

Fusidic Acid
- Counseling

Answer 5

Used for skin infections, decolonization of nares, prophylaxis in catheter surgery