Fuel Use Flashcards
(25 cards)
What are the physiological actions of insulin?
increase glucose uptake by cells
increase glycogenesis
decrease glycogenolysis
decrease gluconeogenesis
What is GSK3?
Phosphorylates glycogen synthase inactivating it, so phosphorylate it to allow glycogen synthesis
What are FOXO genes?
genes which allow gluconeogensis
phosphorylation takes them out of the nucleus
What does p70S6 do?
stimulate protein synthesis
What is the action of insulin on the hepatocyte?
stimulates glycolysis stimulates glycogen synthase stimulates fatty acid synthesis inhibits futile cycling suppresses gluconeogenesis
What enzymes are involved in preventing futile cycling?
PFK2
FBPase-2
What does FBPas-2 do?
inhibits the conversion of F1,6,BP to F-6P
WHat does PFK2 do?
stimulate conversion of F-6P to F1,6BP
How are PFK2 and FBPase activated by insulin?
insulin promotes their dephosphorylation
What are the enzymes involved in the conversion of Acetyl coA to Fatty acids?
acetyl co A carboxylase
fatty acid synthase
What is the action of glucagon?
increases glycogenolysis
increases gluconeogenesis
suppresses glycolysis
What is the signalling pathway of glucagon?
Gas -> AC -> increase cAMP and PKA
How does glucagon suppress futile cycling?
allosterically by phosphorylation
What are the other counter-regulatory responses?
epinephrine, GH, cortisol
At what point do patients experience symptoms of hypoglycaemia?
less than 3mmol/l
At what point do patients experience symptoms of hypoglycaemia?
less than 3mmol/l
What are the main features of diabetes?
hyperglycaemia
glucosuria
EC glucose high with IC glucose low
What are the criteria for diabetes?
FPG >7.0mmol/l
OGTT >11.1mmol/l after 75glucose load
IGT = FPG 7.8 but
What is HbA1c?
gives an average of blood glucose from past three months but can be affected by several factors, including anemia, pregnancy and uraemia
What is the diabetes diagnosis for Hb1AC?
> 6.5%
pre-diabetes 5.7-6.4%
What is the definition of T1DM?
pancreatic b-cell destruction
characterised by the presence of anti-GAD or anti-islet antibodies
What is the definition of T2DM?
diagnosis of exclusion
What other types of diabetes are there?
MODY
Secondary causes
When does T1DM start and how quickly?
childhood/adolescence
very fast
no dyslipidemia
