Gastric Pathology Flashcards Preview

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Flashcards in Gastric Pathology Deck (19):
1

Types of gastric ca

adenocarcinoma (most common and due to H. pylori and envnt factors)
lymphoma
GISTs (muscle, stromal)

2

Red flags for gastric ca

dyspepsia
upper GI bleed
wt. loss
abdo mass
anorexia/early satiety
vomiting

3

Stage stomach cancer by

CT, laparoscopy

4

palliative options for gastric ca=

radio or chemo

5

potentially curative ootions for gastric ca=

surgery with chemo before or after
(too big for radio)

6

Causes of acute gastritis

irritant chemical injury - severe burns, shock, trauma, head injury (stress)

7

Causes of chronic gastritis = (3)

AI
bacterial
chemical

8

AI gastritis is due to _+_ antibodies which
cause _+_ in body of stomach =>
____ anaemia due to __ deficiency
increased risk of ___
get neutro.s with ____

anti-parietal and anti-intrinsic
atrophy and intestinal metaplasia
pernicious/macrocytic ; B12
malignancy
too many lobes

9

Bacterial gastritis is caused by ___ which has a ___ shape
inhabits between the __+_ in the stomach
If not cleared _+_+_+_ build up
___ is crucial

H. pylori
curvilinear
epithelium and mucus layer
lymphocytes, neutro.s, plasma cells which produce anti-H.pylori Ig
IL-8

10

Chronic chemical gastritis is caused by _/_/_
injures mucus layer causing ___+ ___+ lots of ___ are congested and look red
surface is ___

NSAIDs/alcohol/bile reflux (weak pyloric sphincter
hyperplasia and little/no inflam ; capillaries
not smooth

11

The 3 layers of a peptic ulcer top to bottom:

necrotic fibrinopurulent debris
inflamed granulation tissue
fibrotic scar tissue

12

Benign gastric tumours =

hyperplastic or cystic fundic gland polyps

13

H. pylori increase risk of adenocarcinoma by causing chronic ___ which leads to ____/___

gastritis
intestinal metaplasia in the stomach/atrophy

14

Pre-malignancies for gastric adenocarcinoma

H. pylori infection
pernicious anaemia
partial gastrectomy
Lynch syndrome/HNPCC
Menetrier's disease

15

Two subtypes of gastric adenocarcinoma =

intestinal type (localised so = better prognosis)
diffuse type

16

Different types of diffuse gastric adenocarcinoma (3)

expands/infultrates wall = rigid+thickened wall = linitis plastica
signet ring type - mucin (white ) vacuole pushs nucleus to periphery
sclerosis

17

Intestinal type gastric adenocarcinome are __/__ mass with a ___ edge

exophytic/polypoid
raised, rolled edge

18

Gastric adenocarcnoma that spreads to the ovaries =

Kruckenberg

19

____ gastric cancer usually recedes with H. pylori eradication
usually a/symptomatic

Lymphoma/maltoma
asymptomatic