Flashcards in GASTRITIS Deck (23):
Inflammatory condition of the stomach resulting from damage to gastric mucosa.
What type of glandular cells are found in the wall of the body of the stomach?
What type of glandular cells are found in the wall of the antrum of the stomach?
Mucin producing cells
How might someone with suspected acute gastritis present?
What is the pathophysiology of gastritis?
Reduced protection of mucosa or direct epithelial damage
Infiltration of neutrophils
Oedema and congestion
What are some of the risk factors for gastritis?
NSAIDs including aspirin
What are the complications of gastritis?
Erosion and haemorrage
What is chronic gastritis?
Sustained inflammatory response to gastric mucosal damage.
What are the immediate complications of chronic gastritis?
What is the system most commonly used to classify gastritis?
Updated Sydney system
What are the three components of the Sydney System for classifying gastritis?
What are the non-infectious aetiological causes of gastritis?
Autoimmune - (including pernicious anaemia)
Allergy to gluten
What are the infectious aetiological causes of gastritis?
What are the three topographical locations for classifying gastritis?
What percentage of the population are colonised by H. pylori?
Up to 80%
What virulent proteins do some strains of H. pylori have, which makes them more likely to cause gastritis and gastric ulcers and also cancer?
What is autoimmune gastritis?
Chronic gastritis as a result of autoantibodies against the gastrin receptor, ATPase and intrinsic factor (pernicious anaemia), leading to atrophy of the stomach.
What are the complications of autoimmune gastritis?
What other hereditary diseases is autoimmune gastritis associated with?
Type I diabetes mellitus
What are most of the signs and symptoms of autoimmune gastritis attributable to?
The vitamin B12 defiency
How does the body respond to the drop in acid production in autoimmune gastritis?
Increased production and secretion of gastrin leading to hypergastrinemia.
What cells continue to be stimulated by the excessive levels of gastrin in the blood in a patient with autoimmune gastritis? What happens as a result?
Enterochromaffin-like cells (ECL)
Hyperplasia of these cells