Flashcards in Gastrointestinal Blood Flow Deck (18):
Name some characteristics of the regional gastrointestinal circulation
splanchnic circulation = GI tract + spleen
25% of cardiac output perfuses gut
sub-serves motility, secretion, digestion, absorption
storage site for mobilization of blood during exercise
overlap in submucosal arteries preserves arterial flow
The celiac artery perfuses what part of the GI tract?
The superior mesenteric artery perfuses what part of the GI tract?
The inferior mesenteric artery perfuses what part of the GI tract?
What are the mammalian portal venous systems?
What are the 2 most important regulators of blood flow to the GI tract?
What are the effects of autonomic nerves on blood flow to the GI tract?
sympathetic - vasodilation
parasympathetic - increased blood flow in secretory organs, decreased blood flow in smooth muscle
intrinsic - VIP mediated vasodilatation
What are the general hemodynamic effects on blood flow to the GI tract?
decreased cardiac output
decreased arterial pressure
decreased blood volume
decreased fluidity of blood
What is ischemia?
when blood flow is insufficient to deliver an amount of oxygen and nutrients necessary for maintenance or cell integrity
What is reperfusion?
occurs when blood flow is restored to ischemic tissue
What is IR injury?
cellular injury resulting from a period of ischemia followed by restoration of blood flow to ischemic tissue
Explain occlusive ischemia
direct disruption of gastrointestinal blood flow such as strangulation, volvulus, intussusception, or thromboembolism
Explain non-occlusive ischemia
results from systemic conditions such as sepsis
What are the risk factors for gastric dilitation/volvulus?
large and giant breeds
rapid food consumption
one meal per day
What are the principles of management of gastric dilitation/volvulus?
What is associated with intussusception?
What is the therapy for intussusception?
reduction or resection