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Physiology (Gastrointestinal) > Integration of Gastrointestinal Function > Flashcards

Flashcards in Integration of Gastrointestinal Function Deck (14):
1

What are the three types of regulation in the GI tract?

neurocrine
endocrine
paracrine

2

Name the 5 criteria for GI hormones

1. found in gastrointestinal endocrine cells
2. present in blood
3. released by physiologic stimuli
4. infusion of the substance exerts identical effect
5. administration of antibody blocks the physiologic event

3

Name 5 important GI hormones

gastrin
CCK
secretin
somatostatin
motilin

4

What is the classic endocrine effect of gastrin?

gastric acid secretion
pancreatic secretion

5

What is the classic endocrine effect of CCK?

pancreatic secretion
gallbladder contraction

6

What is the classic endocrine effect of secretin?

pancreatic and biliary bicarbonate secretion

7

What is the class endocrine effect of somatostatin?

inhibition of gastrin release, pancreatic secretion, and gallbladder contraction

8

What is the classic endocrine effect of motilin?

interdigestive motility

9

Name the 5 criteria for enteric neuropeptides

1. found in neurons
2. mechanisms for biosynthesis exist
3. concentrated in nerve terminals.
4. released by depolarizing stimuli
5. application of the substance exerts an identical effect

10

Name 6 enteric neuropeptide families

1. tachykinins (ex: substance P)
2. secretin (ex: VIP/PHI)
3. opioids
4. bombesins
5. gastrin-CCK
6. pancreatic polypeptides

11

What is the classic role of enteric neuropeptides?

motility and secretion

12

Name the 4 criteria for paracrine substances

1. found in effector cells
2. released by physiologic stimuli
3. released into extracellular fluid
4. receptors found on target cells

13

Name the 4 paracrine substances

histamine
purines
somatostatin
prostaglandins

14

What is the classic paracrine effect of prostanoids on the gastric mucosal barrier?

increased mucosal blood flow
increased mucous secretion
increased bicarbonate secretion
increased cell turnover