Gene expression in euk

Question 0

How do eukaryotes fit their DNA in chromosomes?

Answer 0

Hey pack it up very tightly to fit them in the nucleus

Question 1

How can heritability be determined?

Answer 1

Using a large population studies in which the phenotype of the offspring are compared to the phenotypes of the general population vs their parents. 80%due to heritability.

Question 2

How are genes kept off

Answer 2

Preventing RNAP from binding to the promoter.

Question 3

How can RNAP be prevented from binding to the promoter?

Answer 3

Methalyte- add ch3 to Cs near the promoter to disguise the sequence
Acetylate- remove acetyl groups from the histone proteins to make overall positive charge of DNA.

Question 4

How is transcription initiated?

Answer 4

Demthylation and histones are acetylated

Then RNAP needs to bind a promoter and be recruited by transcription factors called enhancers. Also stabilize.

Question 5

How can genes that are far away on the transcript coordinate expression?

Answer 5

They bind to the same regulatory transcription factors.