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Flashcards in General Deck (309)
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What is the primary chemotherapeutic drug for ALL?

Asparaginase

1

Primary chemotherapeutic drug for CML

Imatinib

2

DOC for sickle cell anemia

Hydroxyurea

3

DOC for the parasitic infection that can lead to megaloblastic anemia

Praziquantel

(Diphyllobothrium latum)

4

DOC for parasitic infection that can lead to microcytic hypochromic anemia

Albendazole

(hookworms - Necator, Ancylostoma)

5

Rescue therapy for methotrexate

Leucovorin/Folinic acid

6

Rescue therapy for cyclophosphamide

Mesna

7

Rescue therapy for doxorubicin

Dexrazoxane

8

Rescue therapy for cisplatin

Amifostine

9

Treatment for heparin-induced thrombocytopenia

Lepirudin, Agartroban
Direct thrombin inhibitors

10

DOC for outpatient management of lead poisoning

Succimer

11

DOC for malignant hyperthermia

Dantrolene

12

DOC for CMV infection

Ganciclovir

13

None of the cephalosporins are effective against ___________, ____________ & _____________.

Listeria monocytogenes
Enterococci
Methillin-Resistant Staph Aureus

14

DOC for Yersinia pestis

Streptomycin and/or Doxycycline

15

DOC for eradication of chronic carriage of Salmonella in the gallbladder. Why?

Ampicillin

For enterohepatic recycling

16

Drugs that are known to cause pseudo membranous colitis

Clindamycin, Ampicillin, 3rd Generation Cephalosporins

17

Ach is synthesized from acetyl CoA and choline by the enzyme choline acetyltransferase which is inhibited by

Hemocholinium
(cholinergic synthesis)

18

ACh is actively transported into vesicles for storage by vesicle-associated transporter (VAT), inhibited by

Vesamicol
(cholinergic storage)

19

Entry of calcium triggers interaction among SNARE proteins (VAMPs and SNAPs). ______________ toxins alter synaptobrevins to prevent release of ACh.

Botulinium
(cholinergic release)

20

Degradation of ACh into choline and acetate by acetylcholinesterase, inhibited by ____________

Carbamates or organophosphates
(cholinergic termination)

21

Messenger of M1 (nerve endings)

Gq - Increase IP3, DAG cascade

22

Messenger of M2 (heart, some nerve endings)

Gi - Decrease cAMP, activates K channels

23

Messenger of M3 effector cells

Gq - Increase IP3, DAG cascade

24

Used for bladder and bowel atony post surgery

Betanechol

25

Cholinomimetic used for Sjogren syndrome and Sicca syndrome

Pilocarpine

26

Cholinomimetic used for smoking cessation

Varenicline

27

Used in diagnosis of myasthenia gravis

Edrophonium

28

Used in the treatment of myasthenia gravis

Neostigmine

29

Differentiates a cholinergic crisis from a myasthenic crisis

Tensilon test

myasthenic crisis - undermedication
cholinergic crisis - overmedication