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Flashcards in Basic Principles Deck (46)
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1

Any substance that brings about a change in biologic function

Drug

2

Actions of a drug on the body

Pharmacodynamics

3

Actions of the body on the drug

Pharmacokinetics

4

Movement of drug molecules into and within biologic environments

Permeation

5

Most important limiting factor for permeation

Lipid diffusion

6

Aqueous solubility is __________ proportional to electrostatic charge

Directly

7

Lipid solubility is __________ proportional to electrostatic charge

Inversely

8

In weak acids, ___________ form is more water soluble an undergoes better clearance

Unprotonated

9

In weak bases, ___________ form is more water soluble an undergoes better clearance

Protonated

10

Excretion of a weak acid may be accelerated by alkalinizing the urine with _________

Bicarbonate

11

Excretion of a base acid may be accelerated by acidifying the urine with _________

Ammonium chloride

12

Transfer of a drug from its site of administration to the bloodstream

Absorption

13

Most common route of drug administration

Oral route

14

Slowest route of drug administration

Topical

15

Undergoes significant first pass effect

Oral route

16

Partially bypass the first pass effect

Rectal

17

Distribution depends on 4 factors

Size of the organ
Blood flow
Solubility
Binding

18

Drugs may undergo 3 metabolic fates

Termination of drug action
Drug activation
Elimination without metabolism

19

Termination of drug action

Elimination

20

Release of drugs or their metabolites in the urine, stool, bile

Excretion

21

Rate of elimination is proportionate to the concentration

First order elimination

22

Rate of elimination is constant regardless of concentration

Zero order elimination

23

What drugs display zero order kinetics?

WHAT PET
Warfarin
Heparin
Aspirin
Tolbutamide
Phenytoin
Ethanol
Theophylline

24

Translate the drug-receptor interaction into a change in cellular activity

Effectors

25

Response of a particular receptor-effector system measured against increasing drug concentrations

Dose response curve

26

Denotes the amount of drug needed to produce a given effect

Potency

27

Responsiveness diminishes rapidly after administration of a drug

Tachyphylaxis

28

What drugs display tachyphylaxis?

MED Loves CNN in HD
Metoclopramide
Ephedrine
Dobutamine
LSD
Calcitonin
Nitroglycerin
Nicotine
Hydralazine
Desmopressin

29

Continuous activation may lead to depletion of essential substrates

Tolerance

30

Relates the rate of elimination to the plasma concentration

Clearance