Mechanism of Action Flashcards Preview

Pharmacology > Mechanism of Action > Flashcards

Flashcards in Mechanism of Action Deck (272)
Loading flashcards...
0

Used for the vasoocclusive crisis in sickle cell anemia with MOA of increasing HbF

Hydroxyurea

1

Activates muscarinic receptors in ciliary muscle

Pilocarpine

2

Activates nicotinic receptors

Nicotine, Varenicline

3

MOA: Betanechol

Activates muscarinic receptors

4

Inhibits acetylcholinesterase and amplifies endogenousy released acetylcholine

Edrophonium, Neostigmine, Pyridostigmine, Physostigmine, Rivastigmine

5

Competitively blocks all muscarinic receptors

Atropine, Homatropine, Cyclopentelate, Tropicamide

6

Binds phosphorus of organophosphate and breaks organophosphate bond with cholinesterase

Pralidoxime

7

Competitively blocks all muscarinic receptors restoring balance in the basal ganglia

Benztropine

8

Blocks muscarinic receptors in brochial smooth muscle preventing vagal-stimulated bronchoconstriction

Ipatropium, Tiotropium

9

Antagonizes histamine and serotonin

Scopolamine

10

Competitively blocks nicotinic Ach receptors

Hexamethonium, Trimethaptan

11

Activates alpha and beta receptors causing vasoconstriction, increased BP; increased HR, conduction and contractility; and bronchodilation

Epinephrine, Norepinephrine

12

Activates alpha, beta, and dopamine-1 receptors causing vasoconstriction, increased BP; increased HR, conduction and contractility; and vasodilation in sphlanchnic and renal vessels

Dopamine

13

Nonselectively activates beta adrenergic receptors

Isoproterenol

14

Selectively activates alpha-1 adrenergic receptors

Phenylephrine, Pseudoephedrine

15

Activates alpha-2 adrenergic receptors

Clonidine, Methyldopa, Apraclonidine

16

Activates beta-1 adrenergic receptors

Dobutamine

17

Activates beta-2 adrenergic receptors in bronchial smooth muscle causing bronchodilation

Albuterol, Salbutamol
Terbutaline, Ritodrine (uterine smooth muscles also)

18

Irreversibly blocks alpha adrenergic receptors (alpha1>alpha2)

Phenoxybenzamine
(Nonselective alpha blocker)

19

Reversibly blocks alpha adrenergic receptors (alpha1>alpha2)

Phenotolamine
(Nonselective alpha blocker)

20

Selectively blocks alpha-1 adrenergic receptors

Prazosin, Doxazosin, Terzosin, Tamsulosin, Sildosin
(Selective alpha-1 blockers)

21

Blocks beta-1 and beta-2 receptors. Blocks sympathetic effects on heart and BP reducing renin release

Propranolol, Pindolol, Timolol, Labetolol, Carvedilol, Nadolol
(Beta blockers)

22

Selectively blocks beta-1 receptors. Blocks sympathetic effects on heart and BP

Atenolol, Betaxolol, Esmolol, Acebutolol, Metoprolol
(Selective beta-1 blockers)

23

Drugs that causes decreased secretion of aqueous humor from the ciliary epithelium

Timolol (Beta blocker)
Mannitol (Osmotic diuretic)
Apraclonidine (Alpha-2 agonist)
Acetazolamide, Dorzolamide (Carbonic anhydrase inhibitors)

24

Alters intracellular Ca++ metabolism relaxing arteriolar smooth muscle causing vasodilation.

Hydralazine

25

Opens K+ channels in vascular smooth muscle causing hyperpolarization, muscle relaxation and vasodilation

Minoxidil

26

Blocks voltage gated L-type calcium channels (cardiac > vascular)

Verapamil, Diltiazem
(Non-dihydopyridine calcium channel blockers)

27

Blocks voltage gated L-type calcium channels (vascular > cardiac)

Nifedipine, Felodipine, Amlodipine, Nicardipine, Nisoldipine, Israpidine

28

Drugs that cause ciliary muscle contraction, opening of trabecular meshwork, increased outflow

Pilocarpine, Physostigmine
(Cholinomimetics)

29

Its MOA causes increased outflow through canal of Schlemm

Latanoprost