GI: Hepatitis Pharm

Question 1

What is the contraindication of adefovir?

Answer 1

hypersensitivity

Question 2

Would you prescribe Elbasvir/Grazoprevir in someone with cirrhosis?

Answer 2

No

-anyone with severe hepatic impairment, DO NOT prescribe

Question 3

PEG IFN-a-2_ can treat HepB and C, while PEG IFN-a-2_ only treats HepC?

Answer 3

IFN-a-2a=HepB and C

IFN-a-2b=Hep C only

Question 4

BB warning of tenofovir?

Answer 4

Acute exacerbations of HepB when discontinued
Lactic acidosis
Hepatomegaly and steatosis

Question 5

What combo of drugs used to treat HepC are NS5A and NS3/4A inhibitors?

Answer 5

Elbasvir (NS5A)
and
Grazoprevir (NS3/4A)

Question 6

What HepC drug can cause altered taste?

Answer 6

Boceprevir is associated with dysgeusia

Question 7

What drug is a NS3/4A inhibitor used along with PEG-IFN-a and ribavirin?

Answer 7

Boceprevir

Question 8

What drugs can cause flu like symptoms?

Answer 8

PEG IFN-a-2a and b

Question 9

what combo of drugs to treat HepC is only used in junction with ribavirin?

Answer 9

Ledipasvir (NS5A)/Sofosbuvir (NS5B)

Question 10

What combo of drugs causes an increase in ALT levels?

Answer 10

Elbasvir/Grazoprevir

Question 11

What other drug is given along with ribivirin for HepC?

Answer 11

IFN-a-2a

Question 12

What two drugs can cause renal toxicity?

Answer 12

Tenofovir and Adefovir

-so do not prescribe in those w renal issues!

Question 13

What drugs can Elbasvir/Grazoprevir interact with?

Answer 13

Those that interfere with CYP3A

-can increase or decrease concentration

Question 14

Would you prescribe entecavir in someone with HIV?

Answer 14

No, can make it a lot worse

Question 15

What nucleoTide analog is used to treat HepB?

Answer 15

Adefovir

Question 16

BB warning of entecavir?

Answer 16

Acute exacerbations of HepB when discontinued
Lactic acidosis
Hepatomegaly

Question 17

What HepC drug is severely teratogenic?

Answer 17

Ribivirn

-so pregnant mothers and husbands of pregnant mothers beware

Question 18

BB warning for Telbivudine?

Answer 18

Severe exacerbations of HepB when discontinued
Lactic acidosis
Hepatomegaly

Question 19

Both forms of PEG IFN-a are contraindicated in someone with what condition?

Answer 19

Autoimmune hepatitis

Question 20

What nucleoTide analog is used for treatment of HIV and HepB?

Answer 20

Tenofovir disoproxil

Question 21

If a patient is taking amiodarone for their heart arrythmias, what HepC drugs should you not prescribe?

Answer 21

Velpatasvir/Sofosbuvir

-potentiates bradycardia!!

Question 22

What fixed combo of HepC drugs inhibit both NS5A and NS5B?

Answer 22

Ledipasvir (NS5A)/Sofosbuvir (NS5B)

or

Velpatasvir (NS5A)/Sofosbuvir (NS5B)

Question 23

What nucleoSide analogues are used to treat HepB?

Answer 23

Entecavir and Telbivudine

Question 24

BB warning for lamivudine?

Answer 24

Acute exacerbations of HepB when discontinued
Lactic acidosis
Hepatomegaly

Question 25

What nucleoSide is used to treat HepB and HIV?

Answer 25

Lamivudine

Question 26

What can the combo of Telbivudine w PEG IFN-a-2a cuase?

Answer 26

Peripheral Neuropathy

Question 27

What drug can cause pancreatitis?

Answer 27

lamivudine

Question 28

Would you use PEG IFN-a-2a in neonates?

Answer 28

no

Question 29

What drugs should you not prescribe with Velpatasvir/Sofosbuvir?

Answer 29

Amiodarone, B-blockers | -can worsen cardiac/liver comorbidities

Question 30

What drug/drug interactions do you need to watch out for when prescribing Ledipasvir/Sofosbuvir and Velpatasvir/Sofosbuvir?

Answer 30

Poly Glycoprotein inducers (rifampin, St. Johns wart, carbamazepine) -alter concentrations!

Question 31

What is the goal of HBV therapy?

Answer 31

1. Supress HBV DNA 2. Convert HBeAg from positive to neg 3. Reduce AST/ALT

Question 32

What is the goal of HepC therapy?

Answer 32

Eradication of the virus

Question 33

Sofosbuvir inhibit what enzyme?

Answer 33

it is a NS5B polymerase inhibitor

Question 34

The NS3/4 drugs, boceprevir and grazoprevir, inhibit what enzyme?

Answer 34

They function as NS3/4 protease inhibitors