SBL: Dermatology Pharm

Question 1

What should you give for healing diabetic foot ulcers that functions as a PDGF, but also can cause cancer later on?

Answer 1

Becaplermin

Question 2

Bacitracin is great for gram ___ organisms via inhibiting bacterial ___ synthesis.

Answer 2

Gram + organisms and it inhibits cell wall synthesis

Question 3

Neomycin is bacteriocidal or bacteriostatic?

Answer 3

Bacteriostatic by binding 30s of gram (-) organisms

Question 4

Polymixin B is bacteriocidal or bacteriostatic?

Answer 4

Bacteriocidal by altering permeability and damaging cell membranes

Question 5

What can you give topically to treat vulvovaginal candidiasis?

Answer 5

Miconazole or clotrimazole

Question 6

What can you prescribe for 48 weeks to treat onychomycosis?

Answer 6

Efinaconazole

Question 7

What can treat topical dermatophytosis and candidiasis but is also a shampoo for seborrheic dermatitis?

Answer 7

Ketoconazole

Question 8

This topical antifungal is broad spectrum and treats dermatophytes, candida, and malassezia. it also has a low incidence of adverse reactions

Answer 8

Ciclopirox

Question 9

Inhibits squalene epoxidase, effective against dermatophytes but not yeasts; AVOID MUCUS MEMBRANES

Answer 9

terbanifine

Question 10

Which antifungal stunts mycelial growth/distorts hyphae and does not work against candida?

Answer 10

Tolnaftate; only effective against dermatophytes and malessezia

Question 11

This topical antifungal is great for oral candidiasis, but do not swallow or else diarrhea.

Answer 11

Nystatin

Question 12

what is nystatin MOA?

Answer 12

alters membrane permeability allowing electrolytes to leak out

Question 13

What antifungal is limited to cutaneous candida infections and can cause temporal yellow staining of skin?

Answer 13

Amphotericin B

Question 14

This guanosine analogue is great for treating HSV 1/2 herpes labialis?

Answer 14

Acyclovir

Question 15

What is a great Tx for anogenital pruritis?

Answer 15

Topical calcineurin inhibitors

Question 16

Which drug activates TRPV1 to release substance P, and desensitize you to neuropathic itch?

Answer 16

Capsaicin

Question 17

Which local anesthetic is given for facial itching in those with CKD?

Answer 17

Promoxine

Question 18

What type of patch can be used for neuropathic itch?

Answer 18

Lidocaine

Question 19

Rule of thumb for topical steroids?

Answer 19

High potency and titrate down on everywhere but face, genitals and body folds

Question 20

What anti-inflammatory is found in skin products to cause epidermis to shed and dissolve epidermal cement?

Answer 20

Salicylic Acid

Watch out for sun exposure after use

Question 21

What is the a2 agoinst used to treat Rosacea

Answer 21

Briminodine gel

Question 22

What is the a1/a2 agonist used to treat rosacea

Answer 22

Oxymetazoline cream

Question 23

Which organophosphate can kill ectoparasites (lice)?

Answer 23

Malathion

Question 24

Which topical agent does not permit Na+ channels, so no repolarization?

Answer 24

Permethrin

Question 25

Which orally administered drug blocks glutamate gated Cl- channels in InVERtebrates?

Answer 25

Ivermectin

Question 26

What is last resort to kill ectoparasites (lice) due to toxicity?

Answer 26

Lindane is GABAergic

Question 27

Tx mild comedonal acne with?

Answer 27

Topical retinoid

Question 28

Tx mild mixed papular/pustular acne with?

Answer 28

Topical retinoid+topical Ab

Question 29

Tx moderate mixed papular/pustular acne with?

Answer 29

Oral ab+topical retinoid+/-BPO

Question 30

Tx moderate nodular acne with?

Answer 30

Oral ab + topical retinoid + BPO

Question 31

Tx for severe acne?

Answer 31

Oral Isotretinoin

Question 32

What treatment for acne is at risk for pseudomembranous colitis?

Answer 32

Clindamycin

Question 33

What treatment for acne is given once daily at bedtime, cause local flaking and dryness, but also has a fish allergy associated with it?

Answer 33

Tretinoin (ATRA)

Question 34

This plant defense derived dicarboxylic acid is given twice daily to treat moderate acne and post-inflammatory hyperpigmentation?

Answer 34

Azelaic acid

Question 35

Rapid fire.. all used to treat acne: 1. Teeth discoloration and 500mg BID 2. Photosensitivity and 50-100mg BID/150 QD 3. Dizziness, Drug Lupus, and skin discoloration - EXTEDNED RELEASE 4. Steven-Johnson Syndrome/TENS given 800mg bid

Answer 35

1. Tetracycline 2. Doxycycline 3. Minocycline 4. TMP-SMX

Question 36

This hormonal agent is used to treat menstrual cycle related breakouts?

Answer 36

Spironolactone; avoid during pregnancy -spiral is kind of like a cycle?

Question 37

This bad boy can only be given after two negative pregnancy tests and one form of birth control. Highly effective in treating acne though.

Answer 37

Oral Isotretinoine (AKA Accutain)

Question 38

UV light therapies for psoriasis.

Answer 38

UVB=sunburns PUVA - given psoralen, so watch for sun sensitivity - -increases risk for melanoma

Question 39

This drug inhibits PDE4, increases cAMP to decrease NO, TNF-a and then increase IL-10. Given orally to treat psoriasis and psoriatic arthritis.

Answer 39

Apremilast ALAS, its IL-10 from Apremilast. Hazaaah

Question 40

This SubQ injection targets IL-12 and 23 to reduce CD4+, NKs to treat psoriasis, psoriatic arthritis, and Chrons?

Answer 40

Ustekinumab

Question 41

This subQ injection targets IL-17 to reduce chronic inflammation in Psoriasis, psoriatic arthritis, and ankylosing spondylitis.

Answer 41

Se-cukinumab targets IL-Se-venteen

Question 42

Wolff mentioned a couple tx for AKs.. whats the only one he went into detail about?

Answer 42

Topical 5-FU

Question 43

MOA of Topical 5FU

Answer 43

Inhibits thymidylate Synthase to cause destruction of lesions See erythema, blistering, necrosis of lesion

Question 44

Which two drugs are used for advanced BCC?

Answer 44

Sonidegib and vismodegib Inhibit SHH pathway

Question 45

MOA of first line treatment of alopecia?

Answer 45

Minoxidil opens K+ channels to lengthen growth phase, shorten rest phase, and enlarge follicles

Question 46

Pt is taking an oral drug for alopecia that is making him impotent.. what is he taking and why is it doing this?

Answer 46

He is taking finasteride, which inhibits DHT to increase hair count

Question 47

What are some second line tx for allopecia in women?

Answer 47

Spironlactone Finasteride Flutamide

Question 48

How do you manage Alopecia Areata, which is an inflammatory disorder characterized with non-scarring hair loss?

Answer 48

Corticosteroids and Diphenulcyclopropenone (DPCP)