GI Precision & Pearls #2 Flashcards

(50 cards)

1
Q

By definition, toxic megacolon is…

What are some symptoms of this condition?

A

Nonobstructive colonic dilation > 6 cm + signs of systemic toxicity

-Profound bloody diarrhea, vomiting, pain, diarrhea
-Distention
-Fever, AMS, tachycardia, hypotension, dehydration, peritonitis signs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

You need three things to diagnose a patient with toxic megacolon. Name them.

A

-Abdominal radiographs
-3 of the following: fever, pulse > 120, leukocytosis, anemia
-1 of the following: dehydration, AMS, hypotension, lyte abnormalities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Treatment for toxic megacolon

A

-Supportive: decompression with NG tube, bowel rest, ABX (Metro + Ceftriaxone)
-Correct fluid/electrolyte problems
-Steroids if UC is the cause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Diverticulosis is outpouchings due to herniation of mucosa into the wall of the colon. What are some risk factors for this condition?

Symptoms?

A

Constipation, low fiber, obesity

-May be asymptomatic
-Painless hematochezia (MCC of lower GI bleed)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the MCC of a lower GI bleed?

A

Diverticulosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Diverticulosis is MC an incidental finding on a colonoscopy. However, if the bleed is NOT seen on colonoscopy, what diagnostic can you do for this condition?

A

Radionuclide imaging (tech-99)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Treatment for diverticulosis

A

-Most spontaneously resolve
–Resuscitation (2 large bore IV lines/blood products if needed)
-high fiber diet, bran, Psyllium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

On the other hand, diverticulitis is infection/inflammation of the diverticulum. What part of the colon does this MC occur in?

What are the symptoms of this condition?

A

Sigmoid colon

LLQ pain, fever, change in bowel habits, n/v

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What imaging study is done for diverticulitis?

What oral ABX are used in treatment for diverticulitis?

A

CT scan
-Labs show leukocytosis

Oral ABX: Metro + Cipro/Levofloxacin for 7-10 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

With diverticulitis, when should you admit the patient?

A

If complicated (abscess, fistula, perforation) = CT guided percutaneous drainage

If uncomplicated with high risk (sepsis, high fever, old age, immunocompromised)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

A small bowel obstruction, or blockage of the small intestine, MC occurs due to what? Other etiologies, though, include…

A

Post-surgical adhesions (MC)

Others: Malignancy, hernias, volvulus, intussusception

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Symptoms of a small bowel obstruction include CAVO, as well as…

A

Crampy abdominal pain
Abdominal distention
Vomiting
Obstipation (no flatus)

-High pitched tinkles on auscultation
-Visible peristalsis (early) –> hypoactive bowel sounds (late)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Diagnostics done for a small bowel obstruction. What is shown on them?

Upright abdominal XR:

CT scan:

A

XR: multiple air fluid levels in a step ladder appearance

CT: transition zone = dilated loops with contrast to area without contrast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Management for nonstrangulated and strangulated small bowel obstruction

A

Nonstrangulated: NPO, IVF, bowel decompression

Strangulated: Surgery!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

A paralytic ileus is ________. A few etiologies of this are

A

-Decreased peristalsis without mechanical obstruction

-Postoperative state, Opioids, DM, hypothyroidism, hypokalemia, hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the symptoms of a paralytic ileus (how does it differ from a SBO)?

A

Decreased or absent bowel sounds, symptoms like SBO

-However, this is painLESS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What do abdominal XR’s show for a paralytic ileus?

A

Dilated loops of bowel without a transition zone (there is no mechanical obstruction in this case)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Treatment for a paralytic ileus?

A

Supportive: NPO, electrolyte and fluid replacement

NG suction if persistent nausea/vomiting

Encourage walking to get the bowels moving!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is intussusception? Where does it MC occur?

A

Telescoping of an intestinal segment into adjoining segment –> obstruction

Ileocolic junction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Intussusception is the MCC of bowel obstruction in kids < 4 years old. What are risk factors associated with this condition? What is the MCC of this?

A

Children, males, post infections

Idiopathic (MCC), Meckel Diverticulum, Foreign body, Tumors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What symptoms are associated with intussusception?

What diagnostics should you do and what is seen on them?

A

Triad: Vomiting + Abdominal pain + Passage of blood per rectum (currant jelly stools)

-Sausage shaped mass in RUQ
-Emptiness in RLQ (Dance’s Sign)
-Pull knees to chest due to pain

US (initial) = target/donut sign
Air or contrast enema: diagnostic and therapeutic

22
Q

Management for intussusception

A

-Fluid and electrolyte replacement then
-Pneumatic or hydrostatic NG decompression
-Admit for observation

23
Q

A volvulus is twisting of part of the bowel at the mesenteric attachment site. This MC involves what two parts of the colon?

A

Sigmoid colon or cecum

24
Q

Symptoms of a volvulus in an adult.

Symptoms in a neonate

A

-Tympanic abdomen, tenderness, crampy pain, distention, n/v, colicky
-Fever, tachycardia, guarding, rigidity

Neonate: non bilious vomiting within first weeks of life

25
What diagnostics can you do for a volvulus and what is seen?
Abdominal CT: bird beak appearance at site of volvulus Abdominal XR: bent inner tube = U shaped appearance. Closed loop with loss of haustral markings Contrast enema: bird beak appearance
26
Treatment for volvulus
-Endoscopic decompression (proctosigmoidoscopy) Then, elective surgery due to recurrence
27
What is acute mesenteric ischemia? What is the MCC and what are other causes? Symptoms of mesenteric ischemia?
Abrupt onset of small intestine hypoperfusion Emboli from A-fib (MC) Others: Thrombotic (atherosclerosis) = Superior mesenteric artery MC, shock, vasopressors, cocaine Symptoms: Severe abdominal pain out of proportion (poorly localized), n/v, diarrhea
28
Initial diagnostic for acute mesenteric ischemia Definitive diagnostic Labs show leukocytosis and lactic acidosis (elevated lactate is associated with ischemia)
CT angiography initially Arteriography definitive
29
Management for acute mesenteric ischemia
-Surgical revascularization (embolectomy, angioplasty with stent, etc.) -Possible resection -Anticoagulation if associated with A-fib
30
Explain the pathology behind chronic mesenteric ischemia MC it is due to atherosclerotic disease
Decreased supply of blood during times of increased demand (eating)
31
Symptoms of chronic mesenteric ischemia
-Chronic dull abdominal pain worse after meals -Aversion to eating (anorexia) --> weight loss
32
Again, the definitive diagnostic for chronic mesenteric ischemia is.... Treatment?
Angiography Revascularization is the treatment
33
Inflammatory bowel disease includes UC and Crohn's Disease. What are some risk factors for these conditions?
Ashkenazi Jews, 15-35 years old, genetics, infections, western diet, Smoking, Meds (NSAIDs, OCPs, hormone replacement)
34
When thinking about IBD as a whole, what are some extra-intestinal symptoms you should watch for?
Anterior uveitis/iritis Osteoporosis, MSK pain Erythema nodosum B12 deficiency
35
Explain the following for Ulcerative Colitis -Where it takes place -Is rectum always involved? -How deep? -Symptoms (location) -Smoking risk -What is seen on colonoscopy -What is seen on Barium study -Labs -Treatment (is surgery curative as well)
-Limited to colon (begins in rectum with contiguous spread, proximally to colon) -Rectum ALWAYS involved -Mucosa and submucosa only -LLQ pain, colicky, tenesmus, bloody diarrhea -Smoking decreases risk -Colonoscopy: uniform inflammation and pseudopolyps -Barium: Stovepipe sign = decreased haustral markings -Labs: P-ANCA -Treatment: MILD: Topical 5-aminosalicylic acid (ASA) +/- Topical corticosteroids; SEVERE: Oral glucocorticoids + high dose 5-ASA + topical steroids -Surgery is curative in this condition
36
Explain the following for Crohn's Disease -Where it takes place -Is rectum always involved? -How deep? -Symptoms (location) -Smoking risk -What is seen on colonoscopy -What is seen on Barium study -Labs -Treatment (is surgery curative as well)
-Any segment of the GI tract (from mouth to anus) -MC in terminal ileum -Transmural (includes all layers) -RLQ pain, crampy pain, diarrhea (no blood). Perianal disease: fistulas, granulomas, B12/iron deficiency -Colonoscopy: skip lesions and cobblestone appearance -Barium: String sign -Labs: ASCA -Treatment: 5-ASA (Mesalamine) or oral glucocorticoids; SEVERE: Azathioprine, Methotrexate, anti-TNF (-mab) drugs -Surgery NOT curative in this condition
37
Name some symptoms of IBS, as well as some Alarm Symptoms Although this is a diagnosis of exclusion, what is the ROME IV Criteria and what are the components of it?
Abdominal pain with altered bowel habits, diarrhea/constipation alternating, pain relieved with defecation Alarm: GI bleeding, anorexia, weight loss, dehydration ROME IV: Abdominal pain 1 day/week for the last 3 months, plus 2 of the following 3 --Related to defecation --Change in stool frequency --Change in stool appearance
38
What is the treatment for IBS (initially, for constipation, and for diarrhea)
Initially: Lifestyle and diet changes (low fat, high fiber, unprocessed foods). Sleep hygiene. No smoking. Constipation: Fiber, Psyllium, Poly-Glycol Diarrhea: Loperamide, Dicyclomine
39
What is the pathophysiology of celiac disease (Sprue)? What are the symptoms that occur as a result of this patho? Remember the skin finding as well...
Autoimmune-mediated inflammation of the small bowel due to reaction with alpha-gliadin in gluten foods --> loss of villi --> malabsorption Diarrhea, bloating, pain, growth delays Dermatitis herpetiformis: pruritic, papular rash on extensor surfaces, neck, trunk, scalp
40
Screening diagnostic for celiac Definitive diagnostic for celiac
-Transglutaminase IgA antibodies (endomysial IgA antibodies) Small bowel biopsy = atrophy of the villi
41
Treatment for celiac disease
-Gluten free diet (wheat, rye, barley) -Vitamin Supplementation
42
Explain the types of colon polyps -Pseudopolyps: -Hyperplastic: -Adenomatous:
Pseudopolyps due to IBD are not cancerous Hyperplastic: low risk of malignancy (MC non neoplastic type) Adenomatous: MC neoplastic type. --Tubular Adenoma: MC type. Least risk --Villous Adenoma: highest risk
43
Name three genetic disorders that predispose you to having colon polyps
Lynch Syndrome = MC FAP: 100% risk before age 40 Peutz-Jegher's: benign transform to malignant
44
Most colorectal cancers arise from adenomatous polyps. What are other risk factors associated with colon cancer? What are some PROTECTIVE factors?
RF: Age > 50, UC, diet (low fiber, high red meat), obesity, FH, smoking, EtOH Protective: Physical activity, Aspirin, NSAIDs
45
Explain the three genetic disorders to colon polyps -Lynch Syndrome -FAP -Peutz-Jeghers
-Lynch: Nonpolyposis CRC. Due to loss of function of DNA mismatch repair genes FAP: mutation of APC gene. Adenomas in childhood. Cancer by 45 years old 100% chance. Colectomy prophylatically is recommended. Peutz-Jeghers: hamartomatous polyps, mucocutaneous hyperpigmentation, risk of breast and pancreatic cancer
46
Symptoms of colorectal cancer
-Fatigue, weakness (iron deficiency anemia) -Change in bowel habits, bleeding, abdominal pain -large bowel obstruction (CRC MCC) -Right side (proximal): Chronic bleeding -Left side (distal): bowel obstruction, change in stool diameter
47
What is the diagnostic of choice for CRC? What is the best tumor marker for colon cancer?
Colonoscopy with biopsy CEA
48
What is seen on barium enema if the patient has colon cancer?
Apple core lesion
49
Treatment for colon cancer
Surgical resection then chemotherapy if localized Palliative chemotherapy if metastatic
50
Describe the screening recommendations for colon cancer For an average risk, family history risk, Lynch Syndrome, FAP
-Screened until age 75 -Average Risk --Fecal occult test (annually at 50) --Colonoscopy Q10 years of Flex Sigmoidoscopy Q5 -1st degree relative with colon cancer > 60 years old --Fecal occult test (annually at 40) --Colonoscopy Q10 years -1st degree relative with colon cancer < 60 years old --Fecal occult test (annually at 40 or 10 years before diagnosis) --Colonoscopy: Every 5 years -Lynch Syndrome -Start at 20-25 years old via colonoscopy Q1-2 years -FAP -Start at 10-12 years with flexible sigmoidoscopy yearly!