GIST Flashcards
1
Q
GIST Mutation makeup?
A
KIT 75%
PDGFRA 10-15%
WT 10-15%
2
Q
Wild type makeup?
A
Mostly SDH deficient
NF
NTRK
3
Q
KIT exon mutations?
A
Exon 11- stomach, responsive to gleevec
Exon 9- small intestine, less responsive, need double dose, worse prognosis
4
Q
PDGFRA mutations?
A
Better prognosis
Gleevec sensitive(Except Exon 18 and D842V mutations)
5
Q
SDH deficient
A
Mostly gastric
More multifocal, familial
6
Q
Carney triad
A
GIST
Paraganglioma
Pulmonary chordoma
7
Q
Carney-Stratakis syndrome
A
GIST with paraganglioma
Autosomal dominant
8
Q
NF1
A
Multifocal intestinal
9
Q
Duration of therapy with Gleevec
A
3 years minimum
10
Q
Optimal response to Gleevec neoadjuvant
A
3-9 months
