NET classification
Well diff
* G1
* G2
* G3
Neuroendocrine CA
* Small cell
* Large Cell
MiNEN
ZES diagnosis
Gastrin >1000 and pH <2.5 confirmed
Gastrin 100-1000, needs further testing
CLARINET?
Lanreotide for metastatic PNET, or midgut and hindgut
PROMID?
Octreotide for metastatic midgut, functional and non functional
RADIANT?
Everolimus for PNET
Chemo for neuroendocrine?
Cape-Tem
Pembro if TMB high
PRRT?
Peptide receptor radionucleotide therapy
Well/mod diff tumors with SSTR uptake
4 doses 8 weeks apart
NETTER-1
PRRT vs Octreotide for metastatic PNET