GIT 20 ITEMS

Question 1

what is the mechanism by which cimetidine decreases acid secretion

Answer 1

C. competes with histamine for H2 receptor sites

Question 2

which antiulcer medication has an antiandrogenic effect which may cause gynecomastia in some patients

Answer 2

A. cimetidine

Question 3

which anti-gastric ulcer drug binds to mucosal protein substrate and then forms a gel that coats the ulcer

Answer 3

D. sucralfate

Question 4

45 year old man with duodenal ulcer was treated with combination of drugs intended to heal the mucosal damage and to eradicate helicobacter pylori

Answer 4

C. PPI

Question 5

what system is most affected by adverse effects following metoclopromide administration

Answer 5

B. CNS

Question 6

which prokinetic agent may be used in hospitalized patients with acute bowel distention ie Oglivie’s syndrome

Answer 6

C. Neostigmine

Question 7

what is the mechanism by which erythromycin functions as prokinetic agent

Answer 7

A. directly stimulate motilin receptors on gastrointestinal smooth muscle and promotes the onset of a migrating motor complex

Question 8

which laxative is most used for colonic cleansing prior to surgical, radiological or endoscopic procedures

Answer 8

A. balanced polyethylene glycol

Question 9

What are the consequences of prolonged used of stimulant laxatives (cathartics)

Answer 9

A. destruction of myenteric plexus

Question 10

which may be useful in treating constipation by influencing Chloride secretion

Answer 10

A. Lubiprostone Linaclotide Plecanatide

Question 11

Which antidiarrheal medication, chemically related to the potent opioid analgesic meperidine is available over the counter without a prescription

Answer 11

D. LOPERAMIDE

Question 12

which antidiarrheal medication is a synthetic octapeptide that mimics the actions of somatostatin

Answer 12

D. octreotide

Question 13

which anti-diarrheal drug can cause sphincter of Oddi spasm

Answer 13

B. Eluxadoline

Question 14

a 34 year old woman has irritable bowel syndrome with diarrhea is not responsive to conventional therapies. despite the small risk of severe constipation and ischemic colitis, the patient decides to begin therapy with alosetron. Alosetron has which of the following receptor actions

Answer 14

A. 5-HT 3 receptor antagonists

Question 15

which chloride channel activator is approved for the treatment of women with irritable syndrome

Answer 15

C. Lubiprostone

Question 16

5-HT3 antagonist considered as 2nd generation agent with clear superiority over earlier agents

Answer 16

D. palonosetron

Question 17

what autonomic side effect is associated with dronabinol administration

Answer 17

B. conjunctival injection

Question 18

which inflammatory bowel disease medication is mostly commonly lined to diarrhea as a side effect

Answer 18

B. Olsalazine

Question 19

which mesalamine compound contains time-release microgranules that release 5-ASA throughout the small intestine

Answer 19

D. PENTASA

Question 20

what is the preferred beta receptor blocking drug for reducing portal pressures

Answer 20

D. propanolol