NSAID/ GOUT/ RESPI 20 Flashcards
(20 cards)
the ff is a mediator of chronic inflammation
C. interleukins
which of the ff is a conventional synthetic DMARDS
C. leflunomide
the ff statement is not true of aspirin and other related anti-inflammatory drugs
D. stimulate lipooxygenase enzyme
major effects of NSAIDS
all of the above
antipyretic
analgesic
anti-inflammatory
which is not an effect of cyclooxygenase 1 inhibition
C. sodium and water retention
which of the ff is NOT a contraindication to aspirin intake
C. elderly
non-acetylated salicylate that do not inhibit platelet aggregation
c. sodium salicylate
the enzyme irreversibly inhibited by aspirin
C. cyclooxygenase
associated with REYE’S SYNDROME
A. Aspirin
COX-2 selective inhibitors that cause higher incidence of cardiovascular thrombotic events
C. Rofecoxib
A hemophiliac patient with ankle sprain can be safely given with
B. Paracetamol
cox 2 inhibitor with the longest half-life (24 hrs)
D. Lumiracoxib
a non selective COX inhibitor used for cancer pain with bone metastasis and dental surgery
C. Diflunisal
proprionic acid derivative that may afford cardioprotection and marketed as a single enantiomer
C. Naproxen
DMARDS that inhibits aminolmidazole carboxamide ribonucleotide transformylase and thymidilate synthase
A. Methotrexate
NSAID that irreversibly blocks the enzyme cyclooxygenase and acts as a uricosuric agent at high doses (4-5 gms/day)
A. Aspirin
which of the ff is not a clinical use of Aspirin
C. increases the incidence of colon carcinoma
non-selective cox inhibitor that can also inhibit lipoxygenase enzyme
A. ketoprofen
drug used in acute attack of gout that inhibits leukocyte migration and phagocytosis
A. Colchicine
first non-purine inhibitor of xanthine oxidase used in chronic hyperuricemia in gout patients
A. Febuxostat
