TOXICOLOGY 20

Question 1

Expected frequency of the occurrence of an undesirable effect arising from exposure to a chemical or physical agent

Answer 1

B. RISK

Question 2

which of the following is the most effective treatment for severe carbon monoxide poisoning

Answer 2

D. Hyperbaric oxygen therapy

Question 3

which of the ff best describes the typical deposition site and clinical effects of particulate matter sized 2.5-10 microns

Answer 3

B. deposits in upper thoracic airways causing irritation, cough, and upper respiratory symptoms

Question 4

pesticide that interferes with inactivation of the sodium channel and cause repetitive firing of neurons therefore enhances the excitability of neuron

Answer 4

A. organochloride pesticides

Question 5

environmental pollutant that is associated with fibrotic lung diseases, lung cancer and mesothelioma

Answer 5

D. asbestos

Question 6

a 7 year old child is brought to your clinic, he is pale with dark deposit substance along gingival lines. labs reveal microcytic hypochromic anemia with basophilic stippling, which of the following best explains the child’s condition

Answer 6

C. Anemia due to inhibition of heme synthesis lead

Question 7

type of arsenic that is manufactured predominantly for use in semiconductor industry and is associated with hemolytic anemia

Answer 7

A. Arsine

Question 8

brownish irritant airway pollutant from automobile and truck traffuc that is associated with bronchiolitis obliyerans

Answer 8

C. Nitrogen oxide

Question 9

type of pesticide that cause inhibition of ACTHesterase in the esteric site and phosphorylate neuropathy target esterase that can cause demyelination of long nerves

Answer 9

C. Organophosphorus pesticides

Question 10

A 45 year old man presents symptoms of chronic mercury poisoning. laboratory tests confirm elevated mercury levels, the physician considers chelation therapy but avoids using dimercaprol. Why is dimercaprol contraindicated in this patient with chronic mercury poisoning

Answer 10

B. it redistributes mercury to central nervous system

Question 11

chelating agent for contamination of radioactive cesium and intoxication of thalium salts

Answer 11

B. Prussian blue

Question 12

chelating agents that is used to treat wilson’s disease and rheumatoid arthritis

Answer 12

C. Penicillamine

Question 13

24 year old woman, acetaminophen serum concentration drawn 9-hours post-ingestion is above the treatment line. which of the following is the most appropriate next step in management

Answer 13

B. initiate n-acetylcysteine therapy as soon as possible

Question 14

a drug with large volume distribution is most likely to

Answer 14

B. distribute extensively from the blood to other tissue

Question 15

normal anion gap if the formula used omits the potassium lvl

Answer 15

D. 8-12 meq/Lmo

Question 16

most toxic beta blocker

Answer 16

B. Propanolol

Question 17

which vitamin b12 is used for antidotes of cyanide toxicity that combines rapidly with cyanide to form nontoxic cyanocobalamin

Answer 17

A. Hydroxocobalamin

Question 18

sodium thiosulfate is an antidote for cyanide toxicity and acts by

Answer 18

B. providing sulfur donors to convert cyanide into thocyanate

Question 19

what is the primary mechanism by which fomepizole acts in toxic alcohol poisoning

Answer 19

B. Inhibits alcohol dehydrogenase preventing formation of toxic metabolites

Question 20

which of the following is the most appropriate initial step in managing a patient with snake envenomation

Answer 20

B. immobilize the affected limb and transport for antivenom therapy