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FHB Block 3 > Gluconeogenesis > Flashcards

Flashcards in Gluconeogenesis Deck (6)
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1
Q

Glucose homeostasis requires two pathways that take place in the liver. What are they?

A

Gluconeogenesis and glycogen degradation

2
Q

What is gluconeogenesis?

A

The net synthesis of glucose from non-carbohydrate substrates including:

Pyruvate
Lactate
Glycerol
Glucogenic amino acids

3
Q

What is the common intermediate between glycogenolysis and gluconeogenesis?

A

Glucose-6-phosphate

4
Q

What does it cost to convert 1 lactate to 1 molecule of glucose?

A

6 ATP

5
Q

When is gluconeogenesis activated?

A

After dietary glucose has been oxidized and glycogen has been used up

6
Q

What is required for the conversion of pyruvate to PEP?

A

2 step process: Pyruvate –> oxaloacetate —> PEP

Bicarbonate and biotin (cofactor) are also both required, along with ATP