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Flashcards in Lipoprotein Review Slides Deck (34):
1

Where are chylomicrons formed?

The small intestine

2

What is the main lipid in a chylomicron?

TAG

3

What is the main apoprotein component of a chylomicron?

B-48

4

What is the function of a chylomicron?

Transports dietary TAG to adipose and other tissues

5

What is the main lipid of a chylomicron remnant

TAG

6

What is the main apoprotein in chylomicron remnants?

B-48

7

What is the function of a chylomicron remnant?

Delivery of dietary TAG to the liver

It exchanges TAG for CE from HDL and delivers CE to the liver

8

Where is VLDL formed?

In the liver

9

What is the main lipid in VLDL?

TAG

10

What is the main apoprotein in VLDL?

B-100

11

What is the function of VLDL?

Transports endogenously synthesized TAG to adipose tissues (and skeletal and heart tissue)

Exchanges TAG for CE from HDL.

12

WHere is IDL formed?

IDL is a remnant of VLDL. It is formed in the processing of VLDL

13

What is the main lipid in IDL?

TAG and cholesterol

14

What is the main apoprotein in IDL?

B-100, E

15

What is the function of IDL?

Delivers remaining TAG and cholesterol to the liver

16

Where are LDLs formed?

Formed via processing of IDL in the circulation

17

What is the main lipid in LDL?

Cholesterol

18

What is the main apoprotein in LDL?

B-100

19

What is the function of LDL?

Delivers cholesterol to the liver and other cells

20

Where is HDL formed?

The liver, although some is formed in the intestine

21

What is the main lipid in HDL?

Cholesterol

22

What is the main apoprotein of HDL?

A

23

What is the function of HDL?

Transport of CE to the liver

HDL accepts cholesterol from peripheral cells, esterifies it, and transports it to the liver. It exchanges CE for TAG in VLDL, IDL and chylomicron remnants.

It is atheroprotective via enzymes such as paroxonase that inhibit LDL oxidation.

It serves as a reservoir for circulating apoproteins (ACE) which are transported to other lipoprotein particles.

24

What is the major difference between chylomicrons and VLDL, IDL and LDL?

Chylomicrons transport dietary (exogenous) lipids

VLDL, IDL and LDL transport synthesized (endogenous) lipids

25

Apo-CII activates which enzyme?

lipoprotein lipase

26

Apo-AI activates which enzyme?

lecithin:cholesterol acetyltransferase (LCAT)

27

Apo E is the ligand for what receptor?

Remnant receptor

28

Apo B-100 is the ligand for what receptor?

LDL receptor

29

Apo A-1 is the ligand for what receptor?

HDL receptor

30

B-48 is the structural protein for which apolipoproteins?

chylomicrons

31

B-100 is the structural protein for which apolipoproteins?

VLDL and LDL

32

A-1 is the structural protein for which apolipoprotein?

HDL

33

WHat is a normal total cholesterol level?

34

What is the optimal total cholesterol: HDL ratio?

3.3:1