Gonadal hormones Flashcards
(88 cards)
1
Q
anastrozole
A
inhibits aromatase
- decrease effects of estrogen
2
Q
ketoconazole
A
inhibits desmolase
3
Q
letrozole
A
aromatase inhibitor
4
Q
exemestane
A
aromatase inhibitor
5
Q
fulvestrant
A
SERD
6
Q
drospirennone
A
progestin
7
Q
desogestrel
A
progestin
8
Q
toremifene
A
SERM
9
Q
clomiphene
A
SERM
10
Q
norethindrone
A
progestin
11
Q
norgestrel
A
progestin
12
Q
mestranol
A
estrogen
13
Q
nafarelin
A
GnRH analog
14
Q
goserelin
A
GnRH analog
15
Q
Ganirelix
A
GnRH anatagonist
16
Q
mifepristone
A
antiprogestin
17
Q
oxandrolone
A
androgen
18
Q
stanozolol
A
androgen
19
Q
fluoxymesterone
A
androgen
20
Q
nandrolone
A
androgen
21
Q
oxymetholone
A
androgen
22
Q
danazol
A
androgen
23
Q
finasteride
A
5-alpha reducatase inhibitor
24
Q
flutamide
A
androgen receptor antagonist
25
bicalutamide
androgen receptor antagonist
26
nilutamide
androgen receptor antagonist
27
cyproterone
androgen receptor antagonist
28
spironolactone
androgen receptor antagonist
29
ketoconazole
steroid synthesis inhibitor
30
estradiol vs estrone vs estriol - which is most potent
estradiol
31
ethinyl estradiol MOA
stimulation of estrogen receptors = change rate of transcription
relies on P450
32
ethinyl estradiol use
prevent osteoporosis
HRT
OCP
hypogonadism
33
ethinyl estradiol AE
```
breakthrough bleeding
thromboembolism
gallbladder diz
hyperTG
HTN
depression
```
post menopausal women: breast CA, endometrial hyperplasia
**pro-thrombotic drug - blocks AT3
taken with p450 inducer = breakthrough bleeding, dec contraceptive efficacy
34
mestranol
prodrug - converted to ethinyl estradiol
35
dietthlstilbestrol
nonsteroidal estrogen agonist used in pregnancy -- can lead to infertility and vaginal cancer
36
estrogen esters
long acting estrogens - given IM and used for hypogonadism in young females
37
weekly patch
ethinyl estradiol + norelgestromin
38
monthly vaginal ring
ethinyl estradiol + etonogestrel
39
IUD
L-norgestrel
40
subcutaneous implant
etonogestrel
41
depot IM
medroxyprogesterone
42
postcoital contraceptive
L-norgestrel, combined oral contraceptive
43
tx for intractable dysmenorrhea
```
conjugated estrogens
ethinyl estradiol
OCP
depot inejction
GnRH agnoist
```
44
infertility tx
```
progesterone*
clomiphene
hMG and hCG
GnRH analogs
bromocriptine
```
45
endometriosis tx
OCP
depot injection
GnRH agonist
danazol
46
osteoporosis in postmenopausal women
conjugated estrogens
estradiol
raloxifene
47
hirsutism
combined OCP
spirinolactone
flutamide
GnRH agonist
48
progesterone functions
stimulate endometrial glandular secretion
pro-gestation
dec myometrial contraction
inc body temp
thick cervical mucus
prevent endometrial hyperplasia
49
norgestrel AE
weight gain
dec in bone density
**low HDL, inc LDL, HTN**
50
drospirenone
progestin of spironolactone derivative
51
tamoxifen
SERM - estrogen antag at breast and CNS. agonist in endometrium, liver and bone
52
tamoxifen AE
hot flush
thromboembolism
endometrial hyperplasia
53
raloxifene vs tamoxifene
protect against osteoporosis
antagonist effects in breast and CNS and endomterium
**bone density increases with raloxifene
54
clomiphene
induced ovulation
| ER antagonist effect in pituitary = gonadotropin secretion increased
55
clomiphene AE
hyperstimulation of ovary = hypertrophy
multiple pregnancy
hot flush, n/v, weight gain
56
fulvestrant MOA
estrogen antagonist in all tissues = SERD
57
fulvestrant use
tx for hormone responsive breast CA that is resistant to first lines
IM admin
58
fulvestrant AE
hot flush, HA, injection site reactions
59
anastrozole MOA
inhibits aromatase = dec estrogen synthesis
60
anastrozole use
tx for hormone responsive breast CA
oral admin
61
anastrozole AE
musculoskeletal disorder, dec bone density, hot flushes
joint sxs: spondylosis, osteoarhtritis, disk herniation
62
letrozole
similar to anastrozole
63
exemestane
irreversible aromatase inhibitor
64
leuprolide use
```
ovarian suppresion
control ovarian hyperstimulation
central precocious puberty
block endogenous puberty in transgender
adv prostate cancer
```
65
Leuprolide AE
continued use - may show signs of hypogonadism
| light headed, HA, nausea
66
GnRH analogs
```
goserelin
histrelin
nafarelin
triptorelin
gonadorelin
```
67
ganirelix MOA
GnRH antagonist
68
ganirelix use
prevention of premature LH surges during controlled ovulation hyperstimulation
69
cetrorelix
similar to ganirelix
70
degarelix
used for adv prostate CA
71
Danazol
partial agonist of progestin and androgen receptors
*p450 inhibtior
72
danazol use
endometriosis
| fibrocystic breast
73
danazol AE
acne
hirsutism
weight gain
menstrual disturbance
74
mifepristone
antiprogestin
| progestin and glucocorticoid blocker
75
mifepristone use
abortion
76
dihydrotestosterone vs testosterone vs androstenedione - potency?
DHT most potent
77
what drug is used for wasting syndromes?
testosterone - helps with weight gaining
78
oral testosterone
fluoxymesterone
| methyltestosterone
79
long acting androgens for parenteral admins
testosterone esthers
80
finasteride use
BPH
male patterned hair loss
oral admin
81
finasteride AE
impotence
| gynecomastia
82
dutasteride
similar to finasteride
83
flutamide MOA
competitive inhibition of androgen receptor
84
flutamide use
adv prostate cancer
85
flutamide AE
gynecomastia
hot flush
impotence
hepatotoxicity
86
bicalutamide
flutamide like - lower liver toxicity risk
87
nilutamide
flutamide like - lower liver toxicity risk
88
cyproterone
used in hirsutism and to decrease excessive sexual drive in men
