Gonadal hormones Flashcards Preview

PHARM 3 > Gonadal hormones > Flashcards

Flashcards in Gonadal hormones Deck (88)
1

anastrozole

inhibits aromatase
- decrease effects of estrogen

2

ketoconazole

inhibits desmolase

3

letrozole

aromatase inhibitor

4

exemestane

aromatase inhibitor

5

fulvestrant

SERD

6

drospirennone

progestin

7

desogestrel

progestin

8

toremifene

SERM

9

clomiphene

SERM

10

norethindrone

progestin

11

norgestrel

progestin

12

mestranol

estrogen

13

nafarelin

GnRH analog

14

goserelin

GnRH analog

15

Ganirelix

GnRH anatagonist

16

mifepristone

antiprogestin

17

oxandrolone

androgen

18

stanozolol

androgen

19

fluoxymesterone

androgen

20

nandrolone

androgen

21

oxymetholone

androgen

22

danazol

androgen

23

finasteride

5-alpha reducatase inhibitor

24

flutamide

androgen receptor antagonist

25

bicalutamide

androgen receptor antagonist

26

nilutamide

androgen receptor antagonist

27

cyproterone

androgen receptor antagonist

28

spironolactone

androgen receptor antagonist

29

ketoconazole

steroid synthesis inhibitor

30

estradiol vs estrone vs estriol - which is most potent

estradiol

31

ethinyl estradiol MOA

stimulation of estrogen receptors = change rate of transcription

relies on P450

32

ethinyl estradiol use

prevent osteoporosis
HRT
OCP
hypogonadism

33

ethinyl estradiol AE

breakthrough bleeding
thromboembolism
gallbladder diz
hyperTG
HTN
depression

post menopausal women: breast CA, endometrial hyperplasia

**pro-thrombotic drug - blocks AT3

taken with p450 inducer = breakthrough bleeding, dec contraceptive efficacy

34

mestranol

prodrug - converted to ethinyl estradiol

35

dietthlstilbestrol

nonsteroidal estrogen agonist used in pregnancy -- can lead to infertility and vaginal cancer

36

estrogen esters

long acting estrogens - given IM and used for hypogonadism in young females

37

weekly patch

ethinyl estradiol + norelgestromin

38

monthly vaginal ring

ethinyl estradiol + etonogestrel

39

IUD

L-norgestrel

40

subcutaneous implant

etonogestrel

41

depot IM

medroxyprogesterone

42

postcoital contraceptive

L-norgestrel, combined oral contraceptive

43

tx for intractable dysmenorrhea

conjugated estrogens
ethinyl estradiol
OCP
depot inejction
GnRH agnoist

44

infertility tx

progesterone*
clomiphene
hMG and hCG
GnRH analogs
bromocriptine

45

endometriosis tx

OCP
depot injection
GnRH agonist
danazol

46

osteoporosis in postmenopausal women

conjugated estrogens
estradiol
raloxifene

47

hirsutism

combined OCP
spirinolactone
flutamide
GnRH agonist

48

progesterone functions

stimulate endometrial glandular secretion

pro-gestation
dec myometrial contraction

inc body temp

thick cervical mucus

prevent endometrial hyperplasia

49

norgestrel AE

weight gain
dec in bone density

**low HDL, inc LDL, HTN**

50

drospirenone

progestin of spironolactone derivative

51

tamoxifen

SERM - estrogen antag at breast and CNS. agonist in endometrium, liver and bone

52

tamoxifen AE

hot flush
thromboembolism
endometrial hyperplasia

53

raloxifene vs tamoxifene

protect against osteoporosis
antagonist effects in breast and CNS and endomterium

**bone density increases with raloxifene

54

clomiphene

induced ovulation
ER antagonist effect in pituitary = gonadotropin secretion increased

55

clomiphene AE

hyperstimulation of ovary = hypertrophy

multiple pregnancy

hot flush, n/v, weight gain

56

fulvestrant MOA

estrogen antagonist in all tissues = SERD

57

fulvestrant use

tx for hormone responsive breast CA that is resistant to first lines

IM admin

58

fulvestrant AE

hot flush, HA, injection site reactions

59

anastrozole MOA

inhibits aromatase = dec estrogen synthesis

60

anastrozole use

tx for hormone responsive breast CA

oral admin

61

anastrozole AE

musculoskeletal disorder, dec bone density, hot flushes

joint sxs: spondylosis, osteoarhtritis, disk herniation

62

letrozole

similar to anastrozole

63

exemestane

irreversible aromatase inhibitor

64

leuprolide use

ovarian suppresion
control ovarian hyperstimulation
central precocious puberty
block endogenous puberty in transgender
adv prostate cancer

65

Leuprolide AE

continued use - may show signs of hypogonadism
light headed, HA, nausea

66

GnRH analogs

goserelin
histrelin
nafarelin
triptorelin
gonadorelin

67

ganirelix MOA

GnRH antagonist

68

ganirelix use

prevention of premature LH surges during controlled ovulation hyperstimulation

69

cetrorelix

similar to ganirelix

70

degarelix

used for adv prostate CA

71

Danazol

partial agonist of progestin and androgen receptors

*p450 inhibtior

72

danazol use

endometriosis
fibrocystic breast

73

danazol AE

acne
hirsutism
weight gain
menstrual disturbance

74

mifepristone

antiprogestin
progestin and glucocorticoid blocker

75

mifepristone use

abortion

76

dihydrotestosterone vs testosterone vs androstenedione - potency?

DHT most potent

77

what drug is used for wasting syndromes?

testosterone - helps with weight gaining

78

oral testosterone

fluoxymesterone
methyltestosterone

79

long acting androgens for parenteral admins

testosterone esthers

80

finasteride use

BPH
male patterned hair loss

oral admin

81

finasteride AE

impotence
gynecomastia

82

dutasteride

similar to finasteride

83

flutamide MOA

competitive inhibition of androgen receptor

84

flutamide use

adv prostate cancer

85

flutamide AE

gynecomastia
hot flush
impotence
hepatotoxicity

86

bicalutamide

flutamide like - lower liver toxicity risk

87

nilutamide

flutamide like - lower liver toxicity risk

88

cyproterone

used in hirsutism and to decrease excessive sexual drive in men