Bone mineral homeostasis Flashcards Preview

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Flashcards in Bone mineral homeostasis Deck (60)
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1

Magnesium levels effect on PTH secretion

moderate decrease in MG = inc in PTH

SEVERE decline in Mg = drop in PTH secretion

2

common causes of hypomagnesia

diarrhea
diuretics
alcohol abuse
chronic PPI and aminoglycoside use

3

PTH on intestine effect

indirect increase on calcium and phosphate absorption = via increase of vitamin D metabolite

4

PTH on kidney

decreased calcium excretion
increased phosphate excretion

5

Vit D on kidney

increased reabsorption of calcium and phosphate

6

net effect of PTH

increased serum calcium
decreased serum phosphate

7

net effect of vitamin D

increased serum calcium and phosphate

8

fibroblast growth factor 23

made by osteoblasts and osteoclasts = inhibits calcitrol production

dec calcium and phosphate reabsorption in kidney

9

Teriparatide

PTH analog
causes net increase in bone formation/mineralization

10

teriparatide use

osteoporosis

11

teriparatide kinetics

low intermit levels = anabolic effects

chronic admin = can cause primary hyperparathyroidism -- catabolic effects --> osteitis fibrosa cystica

12

teriparatide AE

hypercalcemia - hypercalciuria
osteosarcoma

13

cholecalciferol

vit D analog

14

ergocalciferol

vit D analog

15

cholecalciferol/ergocalciferol use

added to calcium supplements and dairy products

regulates gene transcription via vitamin D receptor

16

cholecalciferol/ergocalciferol use

vit D deficiency
Rickets
osteomalacia

17

Vit D deficient type I

defective 1alpha hydroxylase enzyme

dec calcitriol = dec calcium, dec PO4

18

Vit D deficient type II

defective receptor

19

cholecalciferol/ergocalciferol AE

hypercalcemia, hyperphosphatemia, hypercalciuria

20

calcitriol

1,23-dihydroxyvitamin D3

- management of secondary hyperparathyroidism
- chronic kidney dz
- management of hypocalcemia in pt with hypoparathyroidism
(active form - doesn't require metabolism)

21

doxercalciferol

1alpha-hydroxyvitamin D2

- management of secondary hyperparathyroidism in pt with chronic kidney disease

22

19-nor-1,25-dihydroxyvitamin D2

paricalcitol

-calcitrol analog used for management of secondary hyperparathyroidism in pt with chronic kidney disease

23

calcipotriene

calcipotriol

used for topical tx of psoriasis

calcitriol analog

24

calcitonin

peptide hormone - inhibtis bone resportion

25

calcitonin use

Paget disease
osteoporosis

26

calcitonin kinetics

salmon calcitonin = nasal spray or parenteral

27

calcitonin AE

rhinitis with nasal spray

28

alendronate

bisphosphonate

suppresses osteoclasts and inhibits bone resorption - inhibits osteoclastic activity via dec farnesyl pryophosphate synthesis via disruption of mevalonate pathway decreases osteoclast H+ ATPase

29

alendronate use

osteoporosis
paget's disease

30

alendronate AE

esophageal irrigiation = reduced by drinking ater and remaining upright

osteonecrosis of jaw

adynamic bone