Gout Tx Flashcards

1
Q

Colchicine MOA

A

binds to tubilun to lower polymerization, decrease LTB4, decrease leukocyte migration, decrease granulocyte migration

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2
Q

colchicine SE

A

acute: diarrhea, GI pain
Chronic: hematuria, alopecia, gastritis, myelosuppression, peri. neuropathy

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3
Q

NSAIDs used for acute gout Tx

A

Ibuprophen and Indomethacin

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4
Q

corticosteroids used for acute gout

A

prednisone. methylprednisone

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5
Q

Allopurinol MOA

A

metabolized by xanthine oxidase to become active and then inhibit enzyme

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6
Q

Allopurinol SE

A

rash, hypoxanthine stones

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7
Q

Allopurinol inhibits

A

6-MP metabolism

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8
Q

Probenecid MOA

A

inhibits prox. tubule reabsorption of urate, and inhibits secretion of many acidic drugs

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9
Q

Probenecid needing of what

A

good renal fxn

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10
Q

probenecid SE

A

crystallization of the uric acid, ASA may decrease its effectiveness

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11
Q

Losartan MOA for gout

A

AT1 antagonist with some increase of uric acid secretion

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12
Q

Rasburicase and Pegloticase MOA

A

convert urate to more soluble chemical allantoin

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13
Q

Febuxostat MOA

A

inhibits xanthine oxidase

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