Na channels, Type 1 Anti-arrhtymia Flashcards

1
Q

class IA blocks what

A

fast Na channels, mainly in open or inactivated state

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2
Q

Quinidine other MOA besides Na block

A

also blocks muscarinic and alpha block

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3
Q

Quinidine uses

A

many arrhytmias but like it alot for A-Fib

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4
Q

Quinidine SE

A

cinchonism(tinnitus, ocular dysfxn, CNS excitation, GI distress), hypotension, torsades rhytem

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5
Q

hyperkalemia enhances what with quinidine?

A

V-arrythmia SE

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6
Q

Procainamide class

A

Class Ia

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7
Q

Procainamide metabolism by

A

N-acetyltransferase

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8
Q

Procainamide SE

A

SLE like Sx(+ antihistone), hematotoxicity, CV effects including torsades rhythm

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9
Q

Quinidine class

A

class Ia

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10
Q

class 1B blocks what

A

blocks inactivated Na channel and also the slow Na window current causing decrease of action potential duration (makes plataue phase end faster)

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11
Q

class 1B helps what kind of tissue?

A

blocking their inactivated channels of hypoxic or ischemic tissue

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12
Q

Lidocaine is what class

A

class IB

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13
Q

Lidocaine uses

A

Post MI, open heart surgery, digoxin toxicity

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14
Q

Lidocaine SE

A

CNS toxicity, least cardiotoxic of conventional antiarrythmics, used IV

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15
Q

Mexiletine and Tocainide class

A

class IB

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16
Q

mexiletine and tocainide are…

A

lidocaine derivatives available orally

17
Q

class IC block what

A

block any Na channel shape

18
Q

Flecainide is what class

A

class 1C

19
Q

Flecainide SE

A

VERY high chance for fatal arrythimia