hemostasis Tx

Question 1

Heparin MOA

Answer 1

catalyze the binding of ATIII causing factors IIa, IXa, Xa, XIa, XIIa to be degraded

Question 2

Heparin vs Warfarin can cross placenta?

Answer 2

Warfarin only

Question 3

Warfarin MOA

Answer 3

prevents gamma carboxy of clotting factors by inhbiiting vit k epoxide reductase.,,leads to loss of vit K req. enzymes II, VII, IX, X

Question 4

Heparin SE

Answer 4

heparin induced thrombocytopenia, bleeding, osteoporosis

Question 5

Argatroban special use

Answer 5

DOC in pt who get HIT from heparin

Question 6

Warfarin SE

Answer 6

bleeding, skin necrosis (low protein C), teratogenic (bone dysmorphogenesis), drug interactions

Question 7

Bivalirudin MOA

Answer 7

thrombin inhibitor used for coronary angioplasty and angiography

Question 8

thrombolytic uses

Answer 8

coronary thrombosis in MI, DVT, pulm. embolism, ischemic stroke (tPA)

Question 9

Streptokinase MOA

Answer 9

acts on bound and free plasminogen, bacterial so it is allergenic

Question 10

Alteplase MOA

Answer 10

binds to fibrin to accelerate plasminogen activation, no allergies

Question 11

antidote to streptokinase drugs

Answer 11

aminocaproic acid and treanexamic acids

Question 12

Aspirin MOA

Answer 12

irreverisible block COX

Question 13

Aspirin uses

Answer 13

low dose for prevent MI and recurrence

Question 14

Ticlodipine and clopidogrel MOA

Answer 14

block ADP receptors on platelets to lower activation

Question 15

Ticlodipine SE

Answer 15

leukopenia, thrombocytopenic purpura, hemorrhage

Question 16

Clopedigrel SE

Answer 16

same as ticlodipine but less evident,…leukopenia, thrombocytopenic purpura, hemorrhage

Question 17

abciximab, eptifibatide, tirofiban MOA

Answer 17

inhibit glycoprotein IIb/IIIa receptors to stop aggregation of platelets

Question 18

abciximab, eptifibatide, tirofiban uses

Answer 18

acute coronary syndromes and postangioplasty