Flashcards in Gram positive non-spore forming rods Deck (23)
What lab findings are useful to help diagnose other corynebacterium diptheroids (C. xerosis and D. hofmanli)?
colonies appear more regular than C. Diptheriae
What is the morphology of corynebacterium diptheroids (C. xerosis and C. hofmanli)?
What are the clinical manifestations of other corynebacterium diptheroids (C. xerosis and C. hofmanli)?
acne, otherwise not pathogenic (compare C. diptheriae).
Identify relevant epedemiology and risk factors associated with Listeria monocytogenes. (2)
newborn babies and immunocompromised at increased risk.
T/F: Symptoms of diphtheria include pseudomembranous, pharyngitis, lymphadenopathy, and hematuria.
false. does not cause hematuria.
How is Listeria monocytogenes transmitted? (3)
vertically (across the placenta). During childbirth from mother to child. Eating contaminated food.
What are the clinical manifestations of Corynebacterium diphtheriae? (3)
gray pseudomembrane along airway will bleed if disturbed and obstruct airway. If toxin enters bloodstream: myocarditis, circulatory collapse, weakness and paralysis of cranial nerves
What lab findings are useful to help diagnose Listeria monocytogenes? (5)
small gray colony with narrow zone of betahemolysis on blood agar; tumbling mobility on wet mount; V or L shaped arrangement; gram positive; cold growth
How does Corynebacterium diptheriae gram stain?
How does Listeria monocytogenes gram stain?
What lab findings are useful to help diagnose Corynebacterium diphteriae? (5)
black colonies with brown halos form on a tellurite plate; club shaped gram positive rods; granules (volutin) produced on Loeffler's medium; aerobic; non-spore forming.
What is the morphology of Listeria monocytogenes?
Identify the major virulence/toxicity factors associated with Corynebacterium diphtheriae. (2)
a-b toxin kills surrounding tissue by inhibiting synthesis of ADP ribosylation elongation factor 2. Toxic strains can transform formerly non-toxic strains into toxic strains.
What are the clincal manifestations of Listeria monocytogenes? (2)
meningitis and sepsis in neonates and immunocompromised individuals.
What are the major reservoirs for Listeria monocytogenes? (4)
animals or animal feces; unpasteurized dairy; vegetables; soil
What is the major reservoir for Corynebacterium diphtheriae?
humans are the only natural host.
What is the morpholog of Corynebcterium diphtheriae? What real world object do they resemble?
rod. club shaped
How do the corynebacterium-diptheroids (C. xerosis and C. hofmali) gram stain?
Identify the major virulence/toxicity factors associated with Listeria monocytogenes. (3)
listeriolysin O (a beta-hemolysin) can degrade cell membranes, causing lysis. can grow intracellularly in macrophages. Can grow in cold conditions.
How is Corynebacterium diphtheriae transmitted?
Name the urgent, pathognomic, clinical finding associated with Corynebacterium diphtheriae.
gray pseudomembrane on pharynx is a medical emergency
What is the "most common" associated with Listeria monocytogenes? (2)
most common cause of meningitis in renal transplant patients and adults with cancer.