Immune dysfunction Flashcards Preview

NPLEX - Microbiology and Immunology > Immune dysfunction > Flashcards

Flashcards in Immune dysfunction Deck (14):
1

What is the mechanism of a type III hypersensitivity reaction?

soluble antibody-antigen complexes activate complement and attract inflammatory cells.

2

What are some examples of conditions caused by type III hypersensitivity reactions? (3)

SLE, rheumatoid arthritis, serum sickness

3

What Ig isotypes are common in a type II hypersensitivity reaction? (2)

IgM and IgG

4

What are some examples of type I hypersensitivity reactions? (4)

anaphylactic shock, asthma, hives, local wheal and flare reactions

5

What happens in a type II hypersensitivity reaction?

antibodies bind to a perceived foreign cell and use complement and phagocytosis to kill it.

6

What is the mechanism of a type IV hypersensitivity reaction?

T-cell mediated and therefore delayed

7

What is another name for type I hypersensitivity?

anaphylactic or atopic

8

What is a serum sickness?

a type III reaction to a foreign protein such as an injected drug. It takes about 5-10 days to resolve in most cases and presents with fever, utricara, arthralgia, and proteinuria.

9

What are some examples of conditions caused by type II hypersensitivity reactions? (4)

goodpastures, autoimmune hemolytic anemia, graves disease and rheumatic fever

10

What is another name for type II hypersensitivity?

cytotoxic

11

What are examples of type IV hypersensitivity reactions? (3)

TB skin test, poison ivy, transplant rejection

12

What do type I, II and III hypersensitivity reactions have in common?

they all use antibodies

13

Which cells are involved in type I hypersensitivity? (2)

mast cells and basophils

14

What Ig triggers type I hypersensitivity reactions?

IgE