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Flashcards in Viruses and Prions Deck (161)
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1

What is the morphology of rubivirus (rubella)?

enveloped RNA virus

2

All RNA viruses are ssRNA except ________.

reoviridae-dsRNA

3

What are the clinical manifestations of parainfluenza virus? (2)

croup (parainfluenza type 1) barking cough and sridor, slight fever, most often in the fall. Pneumonia (parainfluenza type 3) in children year round

4

How is hepatitis B transmitted? (3)

blood, sexual intercourse and perinatal transmission

5

What do you see in the peripheral blood in mononucleosis?

atypical lymphocytes (cytotoxic T cells)

6

What do you see in the peripheral blood in mononucleosis?

atypical lymphocytes (cytotoxic T cells)

7

Identify the major virulence factor associated with influenza virus.

secretes neuraminidase which degrades mucous layer of respiratory tract.

8

Which virus is often responsible for pink eye (conjunctivitis)?

adenovirus

9

What is the morphology of cytomegalovirus?

dNA enveloped herpes virus

10

What is the arbovirus mode of transmission?

transmitted by arthropods (mosquitoes, ticks)

11

Name two diseases caused by EBV

infectious mononuelosis, Burkitt's lymphoma

12

How is hepatitis A transmitted?

human to human, fecal to oral

13

What is the morphology of Influenza virus types A, B, C?

segmented RNA orthomyxoviruses, enveloped

14

How is adenovirus transmitted? (3)

respiratory droplets, fecal-oral and fomites

15

What are the clinical manifestations of hepatitis D?

coinfection with HBV increases risk of fulminant hepatitis, cirrhosis

16

Which DNA virus can cause aplastic crises in sickle cell disease?

parvovirus (B19 virus)

17

What Ab is present in those with current HBV infection or are chronic hep B carriers?

HBsAg

18

Identify the major virulence/toxicity factors associated with Epstein-Barr. (2)

has a viral capsid antigen. Infects lymphoid cells (mostly B cells)

19

Prions: Name examples of prion diseases

CJD, kuru, scrapie, mad cow

20

How is prions transmitted?

eating infected tissue (esp nervous tissue). Organ transplants, hGH. Contaminated instruments.

21

Name the route of transmission for VZV.

respiratory secretions

22

Describe the clinical course of respiratory syncytial virus infection. (5)

respiratory disease-1-4 days of incubation, then rhinitis, cough, wheezing and respiratory distress. Pharyngitis.

23

Are MMR (measles, mumps, rubella) vaccines live or 'killed'?

live attenuated

24

Identify the major virulence/toxicity factors associated with measles virus (rubeola). (3)

hemagglutinin helps to penetrate cells. Has cell fusing and hemolytic properties.

25

What are the clinical manifestations of Varicella zoster? (3)

chicken pox 14-21 day incubation followed by pruritic papulovesicular rash over entire body. Mild in children but can cause encephalitis in adults. Herpes zoster (shingles) painful vessicles appear along dermatome of infected sensory nerve. Postherpetic neuralgia possible.

26

What is the major reservoir for cytomegalovirus?

humans

27

What is the morphology of mumps virus?

rNA enveloped paramyxovirus

28

What are the clinical manifestations of influenza virus types A, B, C?

influenza-24-48 hours incubation followed by sudden fever, headache, myalgias and cough

29

Koilocytes are characteristic of what disease?

condylomata acuminata

30

Identify relevant epidemiology and risk factors associated with influenza virus. (2)

type A can change antigens and cause pandemics. Type B may cause local epidemics.