Growth and Endocrine Flashcards
1
Q
What are indications of growth disorders?
A
- extremely tall/short stature
- below target height
- abnormal high velocity (crossing centiles)
- history of chronic disease
- obvious dysmorphic features
- early/late puberty
2
Q
What are common causes of short stature?
A
- familial
- constitutional
- SGA/IUGR
3
Q
What are pathological causes of short stature?
A
- undernutrition
- chronic illness
- iatrogenic (steroids)
- psychological + social
- hormonal (GHD, hypothyroidism)
- syndromes (Turner, P-W)
4
Q
What are investigations for short stature?
A
- FBC + ferritin
- general, coeliac, Crohn’s, JCA
- U + Es, LFTs, Ca, CRP
- coeliac serology + IgA
- IGF-1, TFT, prolactin, cortisol
- karyotype
- Turner’s syndrome
5
Q
What is Consitutional Delay of Growth and Puberty (CDGP)?
A
- boys > girls
- family H
- bone age delay
6
Q
What are some other causes of delayed puberty?
A
- gonadal dysgenesis
- Turner 45X, Klinefelter 47XXY
- chronic disease
- Crohn’s, asthma
- impaired HPG axis
- peripheral
- cryptorchidism
7
Q
What is central prococious puberty?
A
- breast development in girls
- testicular enlargement in boys
- growth spurt
- advanced bone age
8
Q
What is precocious pseudopuberty?
A
- abnormal sex steroid secretion
- gonadotrophin independant
- secondary sexual characteristics
