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Flashcards in Guillain Barre Syndrome Deck (30):
1

Guillain barre syndrome is autoimmune and inflammation to what?

The PNS

2

What is occuring to the PNS in Guillain Barre syndrome?

autoimmune and infammation

3

Guillain barre syndrome is an acute onset of what?

generalized paralysis

4

What is the Et of GBS?

Idiopathic

5

The Patho of Guillain Barre Syndrome is preceeded by what? Over how long?

A Upper respiratory tract infection or a Gastrointestinal infection (1-4 weeks)

6

This preceeding infecting for Guillain Barre Syndrome can be one of two things. Say what each is, and the name of it.

1. Bacteria: Campylobacter jejuni
2. Virus: EBV

7

What is the genous and species name of the bacteria that can lead to GBS?

Campylobacter jejuni

8

What are resevoirs were Campylobacter jejuni can be? (3)

1. Poultry
2. Unpasterized milk
3. Contaminated water

9

The Patho for Guillain Barre Syndrome involves Abs and T cells targgeting what? where?

Myselin sheath in the PNS

10

D/t the Abs and T cells targetting the myelin sheath, there is inflammation. What cells would then be present?

Lymphocytes, macrophages, neutrophils

11

What are the cells that produce the myelin in the PNS? Will they be damaged?

The Schwann cells. Yes, they will be damaged.

12

There can be evidenceo to support autoimmunity is occuring because of what being bound to the Schwan cells?

Abs

13

The mnfts for the infection for Guillain Barre syndrome may or may not be present.. why?

Because the symptoms of the infection may not be present (recovered from the infection) you woulnd't associate the symptoms of GBS together (can come 1-4 weeks later)

14

What is the first mnfts you will see in GBS?

Paresthesias (abnormal sensations such as numbness or tingling)

15

Where do the mnfts typicalling begin?

Peripherals: hands / feet

16

What wil progressively happen after the paresthesias?

progressive ascending muscle weeaknes, which then progresses to...

17

What will progress after the muscle weakness?

Paralysis

18

What manifestation will be felt once the hip or should has been reached?

Deep muscle pain

19

If no intervention is provided to the patient, what will occur to them?

They will become completely paralyzed

20

What would most people die from from GBS? What percentage?

Respiratory failure (~30%)

21

What is used in the Dx of Guillain Barre Syndrome? (4)

1. Hx
2. Physical Exam
3. Decreased Nerve conduction
4. CSF

22

What are you assessing for in the physical exam?

Weakness and tendon reflexes

23

Why are you assessing the CSF?

The peripheral nerves originate in the spinal chord, therefore they may be an increase of proteins in the CSF. ALSO. Trying to rule out other disorders such as MS where you are assessing the CSF.

24

What does protein in the CSF indicate? (1 of 3 things)

1. Compromised BBB
2. Autoimmune Brain or Spinal Chord
3. Inflammation

25

What does the treatment involve for GBS? (4)

1. Maintail vital fx
2. Plasmapheresis
3. IV IgG
4. Pain control

26

Explain the plasmapheresis

Is a process in which the liquid in the blood, or plasma, is separated from the cells. In sick people, plasma can contain antibodies that attack the immune system. A machine removes the affected plasma and replaces it with good plasma, or a plasma substitute

27

Why the IV IgG?

D/T patient having Abs removed, pt. has low immunity therefore replacement Abs is required.

28

Most people with Guillain Barre Syndrome will recover fully or partially? In how long?

Fully in 6-12 months

29

Do patients recovering from Guillain Barre Syndrome typically have any long term impediments?

Typically, no, but sometimes yes.

30

The Etiology of Guillain Barre Syndrome involves autoimmunity that are self targeting based on the MHC/HLA. This means a person would be more at risk if they had genetically defected MHC or HLA proteins on the surface of their cells. What do the Abs then do to the defected MHC or HLA proteins on the surface of the cells?

Abs would be binding to them.