H3.1: Microscopische structuur van de lever (inclusief weekinleiding)

Question 1

kleinste functionerende eenheid lever moet de volgende functies bevatten:

Answer 1

1. duale vasculaire aan- en afvoer
2. duale outflow tracts (vascular and billiary)
3. all known liver functions

Question 2

wat is de kleinste functionerende eenheid van de lever?

Answer 2

bestaat niet 1: er zijn er meerdere voor verschillende contexten:
- lobule (castle)
- acinus (portocentric)(baseballfield)
- metabolic zonation (waar meer zuurstof is, is meer metabolisme)

Question 3

portocentrische verdeling

Answer 3

bij centrale vene is minst goed doorbloed dus drie zones:
periportal1
mid lobulair2
pericentral3

Question 4

portal tract

Answer 4

• portal vein
• bile duct
• arteriol

inbeded in fibrous tissue with some lymphocytes and mast cells and in pheriphery: lymphatic vessels and nerves

Question 5

largest diameter portal tract

Answer 5

vein

a and b have same diameter but b has purple lining

Question 6

hepatocytes

Answer 6

arranged in liver plates of 1 (or 2) cells thick
polygonal with 1 or more nuclei

Question 7

eosinophilic granular and glycogen-rich cytoplasm

Question 8

between the hepatocytes (NOT the liverplates(

Answer 8

bile-canaliculi

Question 9

three specialized regions hepatocytes

Answer 9

1. sinusoidal
2. lateral
3. canaliculair

Question 10

biliary system

Answer 10

bile canaliculi -> canals of hering –> bile ductules -> interlobular bile ducts

Question 11

canals of hering

Answer 11

aan ene kant hepatocyten
aan andere kant cholangiocytes

in deze canals of hering zitten de stamcellen

Question 12

cholangiocyten

Answer 12

• modify composition of bile
• secretion and absorption of water and electrolytes

Question 13

sinusoïdale cellen hebben geen basalmembraan

Answer 13

fenestrated endothelium; wordt erger fenestrated naarmate je naar het midden gaat