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Flashcards in Haem Deck (10):
1

What condition would you see red cell fragments, Heinz bodies and Anaemia?

G6pd deficiency

2

What Hb level counts as anaemia in neonates, infants and children?

Neonates <14g/dl
Infant <10g/dl
Child < 11g/dl

3

What is falconi anaemia?

Genetic disease - often leads to cancer / AML. And bone marrow failure

4

What are the clinical features of sickle cell?

Painful crisis
Haemolytic anaemia (gallstones)
Increased infections (e.g. Pneumococcal)
Stroke/chest syndrome

5

How do you diagnose haemophilia?

Coagulation - prolonged aptt, normal pt and tt, normal platelets.
Haemophillia a - factor 8
HepppEmophilla b - factor 9

6

Which syndromes are associated with platelet disorders?

Glanzmann thrombasthenia (AR- gpIIb-IIIa)

Bernard-soulier syndrome (AR- large platelets low count, lack of gpIb-IX and GpV)

Von willebrand disease (type IIb)

Wiskott-Aldrich syndrome (x-linked, small platelets low count)



7

Most common leukaemia in children?

ALL

8

What are the different types of ALL?

80% B-cell ALL

20% T-cell ALL

9

How does imatinab work in CML?

Tyrosine kinase inhibition specifically targeting the BCR-ABL gene (Philadelphia chromosome t(9;22)

10

What can be given to reduce bleeding in a person with Von willibrands disease after injury and before surgery?

Desmopressin - it is an analogue to ADH, it stimulates the realease of vwf from weibel-palade bodies in endothelial cells