Flashcards in Haem Deck (10):
What condition would you see red cell fragments, Heinz bodies and Anaemia?
What Hb level counts as anaemia in neonates, infants and children?
Child < 11g/dl
What is falconi anaemia?
Genetic disease - often leads to cancer / AML. And bone marrow failure
What are the clinical features of sickle cell?
Haemolytic anaemia (gallstones)
Increased infections (e.g. Pneumococcal)
How do you diagnose haemophilia?
Coagulation - prolonged aptt, normal pt and tt, normal platelets.
Haemophillia a - factor 8
HepppEmophilla b - factor 9
Which syndromes are associated with platelet disorders?
Glanzmann thrombasthenia (AR- gpIIb-IIIa)
Bernard-soulier syndrome (AR- large platelets low count, lack of gpIb-IX and GpV)
Von willebrand disease (type IIb)
Wiskott-Aldrich syndrome (x-linked, small platelets low count)
Most common leukaemia in children?
What are the different types of ALL?
80% B-cell ALL
20% T-cell ALL
How does imatinab work in CML?
Tyrosine kinase inhibition specifically targeting the BCR-ABL gene (Philadelphia chromosome t(9;22)