Haem quiz BARBARA Flashcards
Felty’s syndrome triad
RA, splenomegaly, neutropenia
Cytokine involved in aCD
IL-6 produced by macrophages
ACD pathophysiology
Reduced red cell life span and proliferation
Suppression of EPO
Impaired iron utilisation
Cytokine release
Role of IL-6 IN ACD
IL-6 produced by macrophages which induces hepcidin production by liver, hepcidin retains iron in macrophages and red uces export from enterocytes
someone with a bleeding disorder has their blood mixed with normal plasma and it corrects the disorder, what does this suggest?
That it is a clotting factor deficiency e.g. haemophilia A
Rheumatoid arthritis haematological associations
ACD IDA if taking NSAIDs/ aspirin Neutropenia and thrombocytopenia due to drug toxicity Felty syndrome Raised ESR
Management of TTP
PLASMA EXCHANGE
DO not give platelets as aggravates condition and steroids not needed
Fe, TIBC, transferrin saturation and ferritin in IDA and ACD
IDA: low Fe, high TIBC, v low transferrin saturation and low ferritin
ACD: Low Fe, normal or low TIBC, low transferrin saturation, high ferritin
Why is TIBC low in ACD?
Because there is ample iron but it is not easily accessed
Normal WCC count
4-11x10^9/L
Normal platelet ocunt
150-400 x10^9 cells/L
Blood film findings of neutrophils which indicates an infective cause
Toxic granulation and vacuolation , left shift, rouleaux
Low Hb and HbA2
IDA (helps you differentiate from thalassaemia)
CD5 marker on B cells suggestive of?
CLL
What kind of kinase is JAK2
Tyrosine kinase
