Haematology 8: Lymphoma 1 Flashcards
Which is more common Hodgkin lymphoma or NHL ?
NHL
Where does VDJ recombination occur ?
Bone marrow
Where does class switching occur ?
Germinal centres
Which lymphoma is associated with chronic H.pylori infection?
Gastric MALT lymphoma
Which lymphoma is associated with Coeliac disease ?
EATL - enteropathy-associated T cell Lymphoma
Which virus causes adult T cell lymphoma ?
HTLV1
Which CD marker is a marker of Germinal centre B cells ?
CD10
What does Follicular lymphoma look like on Histology ?
Follicular pattern- lots of follicles in lymph tissue
BCL2 possitive
Which 2 Lymphomas is associated with EBV infection ?
Burkitt’s lymphoma
Hodgkin’s lymphoma
Which lymphoma has a starry-sky appearance
Burkitt’s lymphoma
Which Lymphoma is particularly prevelant in the Caribbean and japan ?
Adult T cell Lymphoma
Which cell allows differentiation between Hodgkin’s and NHL lymphoma ?
Reed-sternberg cells (seen in Hodgkin’s)
looks like Owl eyes
Describe the staging of Hodgkin Lymphoma from 1-4 A/B
Stage 1: one group of nodes
Stage 2: >1 group of nodes same side of diaphragm
Stage 3: nodes above and below the diaphragm
Stage 4: extranodal spread
A: without any B symptoms
B: Fever, Unexplained weightloss of more than 10% in 6 months, night sweats
Name the staging system in Hodgkins lymphoma ?
Ann-Arbor
