Healing And Repair Flashcards
(25 cards)
What is tissue repair characterised by
Formation of a fibrous scar
3 cell types involved in tissue regeneration
Labile,stable, permanent
What are the 2 types of granulation tissue
Vascular and fibrous
What is the growth factor that drives angiogenesis
VEGF
Vascular endothelial growth factor
What are the two types of formation of new capillaries
Sprouting and intussusceptive (splitting)
What is fibrosis
Deposition of collagen to form fibrous connective tissue
What is a hamartoma vs hematoma
Hamartoma is a benign mass of disorganized tissue
Hematoma is the formation of a blood clot at the site of fracture
What are the four stages of soft tissue healing
Clotting
Inflammation
Proliferation
Maturation
Regeneration and restoration is usually acute
Repair is usually due to chronic inflammation
What is regeneration of tissue
Replacement with functional, differentiated cells
Completely functional as before the damage
What is repair of tissue
Production of fibrous scar that may change the tissue structure and potentially the function
Which cells are conditional renewal cells
Stable cells
What are some examples of permanent cells
Nerve fibres, heart, muscle, brain tissue
Granulation tissue is not the same as granulomas
What is granulation tissue
New connective tissue
Fibroblasts function
Makes collagen
Drives process of fibrosis
Formation of new connective tissue
Function of growth factors
Cytokines or hormones that is Produced by many immune cells
Function to PROMOTE CELL SURVIVAL
promote or inhibit cell growth, bind receptors on cell surfaces, homeostasis
If there is a VEGF gradient, what occurs
Sprouting of new blood vessels
Of no gradient, splitting occurs
What cells produces VEGF
Innate immune cells
Examples of growth factors
EGF epidermal growth factor
TGF-alpha transforming growth factor alpha
TGP-beta
FGF fibroblast growth factor stimulates fibroblast proliferation, angiogenesis, epithelial cell regeneration
Growth factors related to M2 macrophages (repair and immune suppression)
TGF-beta
PDGF (platelet derived growth factor)
VEGF
EGF
What occurs during maturation phase
Tissue remodelling of the disorganized granulation tissue
Up to what percentage of tensile strength is regained from tissue remodelling
Cross linking of collagen fibres allows u to regain up to 80% of pre injury strength
Primary vs secondary intentions
Primary only regenration of tissue required
Secondly intention refers to regeneration and repair, scarring involved
Hard tissue repair => fracture healing
How many stages
3
Inflammatory
Repairing
Remodelling
