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Flashcards in HEM&ONC Deck (86)
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1

Shift oxy-hemoglobin curve to left

Metabolic alkalosis Decreased body temp Increased Hgb F

2

Shift oxy0hemoglobin curve to the right

Metabolic acidosis Increased body temp High altitude Exercise

3

5 causes of microcytic anemia

Iron deficiency Lead poisoning Anemia of chronic disease Sideroblastic anemia Thalassemias

4

3 causes of normocytic anemia

Hemolytic anemia Anemia of chronic disease Hypovolemia

5

Normal MCV Increased retake count Increased indirect bill Increased LDH Decreased serum haptoglobin

Hemolytic anemia

6

Pathology of G6PD deficiency

Deficiency of G6PD (enzyme required to repair oxidative damage to RBCs) Ingestio nof an oxidant causes excessive hemoylsis

7

Heinz bodies

Small densities of Hgb in RBC seen in GG6PD deficiency

8

Oxidants that exacerbate G6PD deficiency

Fava beans High dose ASA Sulfa Dapsone Quinine/quinidine Primaquine Nitrofurantoin

9

Serum iron and ferritin in sideroblastic anemia

Increased

10

Which thalassemia shows basophilic stippling

Beta

11

Gingival lead lines, peripheral neuropathy, decreased MCV

Lead poisoning anemia (acquired sideroblastic anemia)

12

Treamtnet for lead poisoning

EDTA or Dimercaptosuccinic acid

13

Drugs that can cause aplastic anemia

Chloramphenicol, sulfonamides, phenytoin, chemotherapeutics

14

H/P of aplastic anemia

Persistent infections Poor clotting Easy brusiing

15

Defective heme synthesis

Sideroblastic anemia

16

Causes of sideroblastic anemia (3) - acquired

Alcohol Isoniazid Lead poisoning

17

Tx of hereditary sideroblastic anemia

Vitamin B6. Significant iron overload requires therapeutic phlebotomy or chelation with deferoxamine.

18

Complication in 10% of sideroblastic anemia patients

Acute leukemia

19

SORE tongue points to what kind of anemia

folate deficiency

20

How many abnormal genes do pts with alpha thalassemia minor have

Two

21

What kind of Hb increases in pts with B-thalassemia minor

HbA2

22

What kind of Hb is increased in pts with B-thalassemia major

HbA2 and F

23

Complications of thalassemias

Chronic iron overload from repeat transfusions causes damage to heart and liver.

24

Diff between sickle cell anemia and beta thalassemia

SCD causes production of DEFECTIVE beta chains. In B-thalassemia, decreased production of NORMAL beta chains.

25

"fish mouth vertebrae"

sickle cell disease

26

Encapsulated organisms

S pneumo H influenzae N. meningitidis Klebsiella

27

What type of hypersensitivity is drug-induced hemolytic anemia

Type II

28

Increased PT/INR indicates decreased function of which factors

Factors II, VII, IX, X

29

Increased PTT indicates decreased function of which factors

IIa, IXa, Xa, XIa, XIIa

30

Monitoring required in LMWH

None :)