HEMA

Question 1

Drugs that carry DEFINITE risk of clinical hemolysis in persons with G6pd

Answer 1

Question 2

Drugs that carry DOUBTFUL risk of clinical hemolysis in persons with G6pd

Answer 2

Quinine, sulfisoxazole, sulfadiazine, chloramphenicol, pamnisalicylic acid, Paracetamol, phenacetin, doxorubin, probenecid

Question 3

Diagnosis of Microcytic anemia

Answer 3

Question 4

elevated hgb approach (memorize the figure!)

Answer 4

Question 5

Overt DIC criteria

Answer 5

<5 low grade
>5 overt DIC

Question 6

pathophysiology of DIC?

Answer 6

• uncontrolled thrombin generation
• fibrin deposits in the microcirculation
  -consumption of platelets and coags
  ischemic tissue dammage
  RBC damage and hemolysis

Question 7

therapuetic uses of GMCSF and G CSF

Answer 7

Question 8

phenotypic characteristics of malignant cells

Answer 8

Question 9

preventice uses of GMCSF and G CSF

Answer 9

Question 10

criteria for the initiation of therapy for CLL

Answer 10

• evidence of progressive marrow failure,
  -massive progressive or symptomatic splenomegaly
  massive >10cm lymphadenopathy
  progressive lymphocytosis with an increase of >50% over a 2 month period or lymphocyte doubling time <6 months
  autoimmune anemia or thrombovytopenia not responsive to standard therapy
  symptomatic or functional extranodal involvement
  contitutional symptoms

Question 11

disgnostic criteria for MGUS

Answer 11

Question 12

Dx criteria for Asymptomatic myeloma/ smoldering MM

Answer 12

Question 13

Dx criteria for symptomatic multiple myeloma

Answer 13

Question 14

Dx of nonsecretory myeloma

Answer 14

Question 15

Dx of solitary plasmacytoma

Answer 15

Question 16

Dx of POEMS syndrome

Answer 16

Question 17

Tx for multiplemyeloma (classes)

Answer 17

Question 18

IDH 1 target tx for AML

Answer 18

IVOsidenib

Question 19

FTL3 inhibitor for AML

Answer 19

GILTErinib

Question 20

tx for CLL, SLL, FL
P13k delta inhibitor, preventing proflireation and inducing apopotosis

Answer 20

IDELAlisib

Question 21

tx for Breast CA with PIK3CA mutation

Answer 21

ALPELISIB

Question 22

MABs for tx for cancer
(memorize)

Answer 22

Question 23

antibody chemotherapy conjugates for tx of CA

Answer 23

Question 24

CAR Tcell inhibitor for ALL

Answer 24

Question 25

EGFT inhibidor for colon cancer squamous cell carcinoma of the head and neck

Answer 25

CETUXimab

Question 26

Fully humanized egfr inhibitor for colon cnacer

Answer 26

PANITUMUMAB