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HML II > Hematinics and GFs > Flashcards

Hematinics and GFs Flashcards

1
Q

Erythrocyte factors used in anemias

A

Iron
Vit B12
Folate
Erythropoiesis stimulating agents

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2
Q

Platelet factor used in anemias

A

Oprelvekin (IL-11)

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3
Q

Granulocyte factors used in anemias

A

Filgrastim (G-CSF)
Sargramostim (GM-CSF)

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4
Q

Drug interactions of oral iron

A

Reduced absorption of tetracyclines, fluoroquinolones, levothyroxine, and vit E by iron chelation

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5
Q

Symptoms of acute iron toxicity

A

Gastroenteritis
Vomiting
Metabolic acidosis
Shock
Coma

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6
Q

Treatment for acute iron toxicity

A

Whole bowel irrigation
Deferoxamine

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7
Q

Mechanism of deferoxamine

A

Iron chelating agent

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8
Q

Causes of chronic iron toxicity

A

Hemochromatosis
Frequent red cell transfusions

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9
Q

Treatments for chronic iron toxicity

A

Phlebotomy
Iron chelating agents

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10
Q

Clinical uses of vit B12

A

Pernicious anemia
Anemia post-gastric resection

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11
Q

Types of erythropoiesis stimulating agents

A

Epoetin alfa –> recombinant human
Darbepoetin alfa

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12
Q

Side effects of erythropoiesis stimulating agents

A

HTN
Thrombosis

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13
Q

Myeloid growth factor that increases the production of neutrophils only

A

G-CSF –> filgrastim

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14
Q

Myeloid growth factor that increases the production of neutrophils, eosinophils, basophils, and monocytes

A

GM-CSF –> sargramostim

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15
Q

Adverse effect of filgrastim

A

Bone pain

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16
Q

Adverse effects of sargramostim

A

Fever
Arthralgias
Capillary damage

17
Q

Types of megakaryocyte growth factors used to treat thrombocytopenia

A

Oprelvekin
Romiplostim
Eltrombopag

18
Q

Adverse effects of oprelvekin

A

Fatigue
HA
Fluid retention

19
Q

Thombopoietin receptors agonists

A

Romiplostim
Eltrombopag

20
Q

Adverse effects of eltrombopag

A

Hepatotoxicity
Hemorrhage

HML II (15 decks)

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